Association between HMGB1 and COPD: A Systematic Review
HMGB1 is an alarmin, a protein that warns and activates inflammation. Chronic obstructive pulmonary disease (COPD) is characterised by a progressive airflow obstruction and airway inflammation. Current anti-inflammatory therapies are poorly effective in maintaining lung function and symptoms of COPD...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/164913 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832552412783575040 |
|---|---|
| author | Sebastiano Gangemi Marco Casciaro Giovanni Trapani Sebastiano Quartuccio Michele Navarra Giovanni Pioggia Egidio Imbalzano |
| author_facet | Sebastiano Gangemi Marco Casciaro Giovanni Trapani Sebastiano Quartuccio Michele Navarra Giovanni Pioggia Egidio Imbalzano |
| author_sort | Sebastiano Gangemi |
| collection | DOAJ |
| description | HMGB1 is an alarmin, a protein that warns and activates inflammation. Chronic obstructive pulmonary disease (COPD) is characterised by a progressive airflow obstruction and airway inflammation. Current anti-inflammatory therapies are poorly effective in maintaining lung function and symptoms of COPD. This underlines the need for finding new molecular targets involved in disease pathogenesis in order to block pathology progression. This review aims to analyse latest advances on HMGB1 role, utilisation, and potential application in COPD. To this purpose we reviewed experimental studies that investigated this alarmin as marker as well as a potential treatment in chronic obstructive pulmonary disease. This systematic review was conducted according to PRISMA guidelines. In almost all the studies, it emerged that HMGB1 levels are augmented in smokers and in patients affected by COPD. It emerged that cigarette smoking, the most well-known causative factor of COPD, induces neutrophils death and necrosis. The necrosis of neutrophil cells leads to HMGB1 release, which recruits other neutrophils in a self-maintaining process. According to the results reported in the paper both inhibiting HMGB1 and its receptor (RAGE) and blocking neutrophils necrosis (inducted by cigarette smoking) could be the aim for further studies. |
| format | Article |
| id | doaj-art-1248e033f6a04a239d88ea59c849bd33 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-1248e033f6a04a239d88ea59c849bd332025-02-03T05:58:42ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/164913164913Association between HMGB1 and COPD: A Systematic ReviewSebastiano Gangemi0Marco Casciaro1Giovanni Trapani2Sebastiano Quartuccio3Michele Navarra4Giovanni Pioggia5Egidio Imbalzano6School and Operative Unit of Allergy and Clinical Immunology, Department of Clinical and Experimental Medicine, University Hospital “G. Martino”, University of Messina, 98125 Messina, ItalySchool and Operative Unit of Allergy and Clinical Immunology, Department of Clinical and Experimental Medicine, University Hospital “G. Martino”, University of Messina, 98125 Messina, ItalyDepartment of Clinical and Experimental Medicine, University of Messina, 98125 Messina, ItalyDepartment of Clinical and Experimental Medicine, University of Messina, 98125 Messina, ItalyDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, University Pole Annunziata, 98168 Messina, ItalyInstitute of Applied Sciences and Intelligent Systems (ISASI), Messina Unit, 98100 Messina, ItalyDepartment of Clinical and Experimental Medicine, University of Messina, 98125 Messina, ItalyHMGB1 is an alarmin, a protein that warns and activates inflammation. Chronic obstructive pulmonary disease (COPD) is characterised by a progressive airflow obstruction and airway inflammation. Current anti-inflammatory therapies are poorly effective in maintaining lung function and symptoms of COPD. This underlines the need for finding new molecular targets involved in disease pathogenesis in order to block pathology progression. This review aims to analyse latest advances on HMGB1 role, utilisation, and potential application in COPD. To this purpose we reviewed experimental studies that investigated this alarmin as marker as well as a potential treatment in chronic obstructive pulmonary disease. This systematic review was conducted according to PRISMA guidelines. In almost all the studies, it emerged that HMGB1 levels are augmented in smokers and in patients affected by COPD. It emerged that cigarette smoking, the most well-known causative factor of COPD, induces neutrophils death and necrosis. The necrosis of neutrophil cells leads to HMGB1 release, which recruits other neutrophils in a self-maintaining process. According to the results reported in the paper both inhibiting HMGB1 and its receptor (RAGE) and blocking neutrophils necrosis (inducted by cigarette smoking) could be the aim for further studies.http://dx.doi.org/10.1155/2015/164913 |
| spellingShingle | Sebastiano Gangemi Marco Casciaro Giovanni Trapani Sebastiano Quartuccio Michele Navarra Giovanni Pioggia Egidio Imbalzano Association between HMGB1 and COPD: A Systematic Review Mediators of Inflammation |
| title | Association between HMGB1 and COPD: A Systematic Review |
| title_full | Association between HMGB1 and COPD: A Systematic Review |
| title_fullStr | Association between HMGB1 and COPD: A Systematic Review |
| title_full_unstemmed | Association between HMGB1 and COPD: A Systematic Review |
| title_short | Association between HMGB1 and COPD: A Systematic Review |
| title_sort | association between hmgb1 and copd a systematic review |
| url | http://dx.doi.org/10.1155/2015/164913 |
| work_keys_str_mv | AT sebastianogangemi associationbetweenhmgb1andcopdasystematicreview AT marcocasciaro associationbetweenhmgb1andcopdasystematicreview AT giovannitrapani associationbetweenhmgb1andcopdasystematicreview AT sebastianoquartuccio associationbetweenhmgb1andcopdasystematicreview AT michelenavarra associationbetweenhmgb1andcopdasystematicreview AT giovannipioggia associationbetweenhmgb1andcopdasystematicreview AT egidioimbalzano associationbetweenhmgb1andcopdasystematicreview |