The P2X7 receptor in depression: Novel insights and therapeutic implications

The P2X7 receptor in depression: Novel insights and therapeutic implications

Major depressive disorder (MDD) is a heterogeneous mental disorder involving multiple pathogenic mechanisms. Current first-line antidepressant medications suffer from slow onset of action, limited effectiveness, and high side effects, necessitating the search for new therapeutic targets. Targeting c...

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Bibliographic Details
Main Authors: Yue-ting Zhong, Chao Pi, Ying Zuo, Yan Wei, Wen Li, Yong-qiang Jiang, Lei Tao, Wen-wu Zheng, Jun Jiang, Yan Yang, Shi-feng Chu, Bin-yan Liu, Ke-zhi Liu, Yu-meng Wei, Ling Zhao
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Neurobiology of Disease
Subjects:
Depression
P2X7 receptor
Neuroinflammation
Oxidative stress
Mitochondrial dysfunction
Synaptic plasticity
Online Access:http://www.sciencedirect.com/science/article/pii/S096999612500227X
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