Low dose deltamethrin exposure affects gene expression in rat frontal cortex
Pyrethroids are a class of commonly used synthetic insecticides, widely used in agricultural and residential settings due to their efficacy and relatively low environmental impact. Nonetheless, epidemiological studies have found that exposure to pyrethroids during developmental stages is linked to...
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| Language: | English |
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The University of Toledo
2025-02-01
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| Series: | Translation |
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| Online Access: | https://openjournals.utoledo.edu/index.php/translation/article/view/1362 |
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| author | Junze Wu Ariv Shah Rami Ridi Zacharia Rashid Ali Sajid Imami Nilanjana Saferin James Patrick Burkett |
| author_facet | Junze Wu Ariv Shah Rami Ridi Zacharia Rashid Ali Sajid Imami Nilanjana Saferin James Patrick Burkett |
| author_sort | Junze Wu |
| collection | DOAJ |
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Pyrethroids are a class of commonly used synthetic insecticides, widely used in agricultural and residential settings due to their efficacy and relatively low environmental impact. Nonetheless, epidemiological studies have found that exposure to pyrethroids during developmental stages is linked to risk for neurodevelopmental disorders. However, the molecular mechanisms behind these neurotoxic effects remain unclear. Our study investigates the impact of oral exposure to deltamethrin, a widely used Type II pyrethroid pesticide, on gene expression in the frontal cortex of rats. We used differential gene expression data from frontal cortex dissections from male Long-Evans rats exposed to a 3 mg/kg oral dose of deltamethrin (or vehicle) to perform a 3Pod analysis in R Studio, which included GSEA, Enrichr, and iLINCS analyses. We found that rats who were exposed to deltamethrin had significant changes in gene expression in cortex in pathways related to inflammation, apoptosis, cellular energy metabolism, and synapses. Our study provides important insight on the effects of pesticide exposure on the brain and possible treatments and preventions. This study also emphasizes the need for further research on pyrethroid pesticides and their relationship to neurodevelopmental disorders.
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| format | Article |
| id | doaj-art-123632cc5cb44eeeac2b76f082873304 |
| institution | Kabale University |
| issn | 2469-6706 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | The University of Toledo |
| record_format | Article |
| series | Translation |
| spelling | doaj-art-123632cc5cb44eeeac2b76f0828733042025-02-05T18:17:54ZengThe University of ToledoTranslation2469-67062025-02-0113S110.46570/utjms-2025-1362Low dose deltamethrin exposure affects gene expression in rat frontal cortexJunze Wu0Ariv Shah1Rami Ridi2Zacharia Rashid3Ali Sajid ImamiNilanjana SaferinJames Patrick BurkettSummer Biomedical Science Program in Bioinformatics 2024, Department of Neurosciences, College of Medicine and Life Sciences, University of Toledo, Toledo, OH 43614, USASummer Biomedical Science Program in Bioinformatics 2024, Department of Neurosciences, College of Medicine and Life Sciences, University of Toledo, Toledo, OH 43614, USASummer Biomedical Science Program in Bioinformatics 2024, Department of Neurosciences, College of Medicine and Life Sciences, University of Toledo, Toledo, OH 43614, USASummer Biomedical Science Program in Bioinformatics 2024, Department of Neurosciences, College of Medicine and Life Sciences, University of Toledo, Toledo, OH 43614, USA Pyrethroids are a class of commonly used synthetic insecticides, widely used in agricultural and residential settings due to their efficacy and relatively low environmental impact. Nonetheless, epidemiological studies have found that exposure to pyrethroids during developmental stages is linked to risk for neurodevelopmental disorders. However, the molecular mechanisms behind these neurotoxic effects remain unclear. Our study investigates the impact of oral exposure to deltamethrin, a widely used Type II pyrethroid pesticide, on gene expression in the frontal cortex of rats. We used differential gene expression data from frontal cortex dissections from male Long-Evans rats exposed to a 3 mg/kg oral dose of deltamethrin (or vehicle) to perform a 3Pod analysis in R Studio, which included GSEA, Enrichr, and iLINCS analyses. We found that rats who were exposed to deltamethrin had significant changes in gene expression in cortex in pathways related to inflammation, apoptosis, cellular energy metabolism, and synapses. Our study provides important insight on the effects of pesticide exposure on the brain and possible treatments and preventions. This study also emphasizes the need for further research on pyrethroid pesticides and their relationship to neurodevelopmental disorders. https://openjournals.utoledo.edu/index.php/translation/article/view/1362pyrethroidspesticidesexposure scienceNeurotoxicity |
| spellingShingle | Junze Wu Ariv Shah Rami Ridi Zacharia Rashid Ali Sajid Imami Nilanjana Saferin James Patrick Burkett Low dose deltamethrin exposure affects gene expression in rat frontal cortex Translation pyrethroids pesticides exposure science Neurotoxicity |
| title | Low dose deltamethrin exposure affects gene expression in rat frontal cortex |
| title_full | Low dose deltamethrin exposure affects gene expression in rat frontal cortex |
| title_fullStr | Low dose deltamethrin exposure affects gene expression in rat frontal cortex |
| title_full_unstemmed | Low dose deltamethrin exposure affects gene expression in rat frontal cortex |
| title_short | Low dose deltamethrin exposure affects gene expression in rat frontal cortex |
| title_sort | low dose deltamethrin exposure affects gene expression in rat frontal cortex |
| topic | pyrethroids pesticides exposure science Neurotoxicity |
| url | https://openjournals.utoledo.edu/index.php/translation/article/view/1362 |
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