Assessment of Antidiabetic Potential and Phytochemical Profiling of Viscum album, a Traditional Antidiabetic Plant
The traditional antidiabetic plant Viscum album (V. album) was collected from the oak plant in the wild at Maidan, Khyber District, of Pakistan, for assessment of its antidiabetic potential and phytochemical profile. Lowering of blood glucose level, antioxidant effect, lipids profile, liver function...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Journal of Food Quality |
| Online Access: | http://dx.doi.org/10.1155/2022/5691379 |
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| author | Manzoor Ullah Sultan Mehmood Rehmat Ali Khan Maroof Ali Fozia Fozia Muhammad Waqas Riaz Ullah Amal Alotaibi Mujeeb A. Sultan |
| author_facet | Manzoor Ullah Sultan Mehmood Rehmat Ali Khan Maroof Ali Fozia Fozia Muhammad Waqas Riaz Ullah Amal Alotaibi Mujeeb A. Sultan |
| author_sort | Manzoor Ullah |
| collection | DOAJ |
| description | The traditional antidiabetic plant Viscum album (V. album) was collected from the oak plant in the wild at Maidan, Khyber District, of Pakistan, for assessment of its antidiabetic potential and phytochemical profile. Lowering of blood glucose level, antioxidant effect, lipids profile, liver function marker enzymes, and kidney function markers were evaluated in extract and glibenclamide treated groups, in normal as well as in diabetic control groups. An elevated level of blood glucose level, lipids (Cholesterol, TG, LDL), liver function marker enzymes (ALT, AST, ALP), and kidney function markers (bilirubin, creatinine, urea) were observed in alloxan-induced diabetic rats; however, a HDL level was decreased. Administration of V. album hydroalcoholic extract for 28 days renovated significantly (p<0.05) all the above biochemical parameters. The antioxidant enzymes SOD, CAT, and GPX were also considerably restored. In vitro, antioxidant assay indicated that the extract of 2,000 µg/mL scavenges free radicals of DPPH 68.4%, ABTS 69.5%, and H2O2 50.6%. The extracts revealed the presence of saponins, flavonoids, alkaloids, terpene, tannins, phenols, protein, amino acids, sterols, and glycosides. The extract has shown phenolic contents 421 ± 4.8 mg GAE/100 g d. w and flavonoids content 127 ± 1.4 mg equiv. Rut/100 g d. w. The findings of this research recommend V. album could be a potent source of natural antidiabetic constituents. |
| format | Article |
| id | doaj-art-122e00b9a8b84f9a979555e152a3b164 |
| institution | Kabale University |
| issn | 1745-4557 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Food Quality |
| spelling | doaj-art-122e00b9a8b84f9a979555e152a3b1642025-02-03T01:06:53ZengWileyJournal of Food Quality1745-45572022-01-01202210.1155/2022/5691379Assessment of Antidiabetic Potential and Phytochemical Profiling of Viscum album, a Traditional Antidiabetic PlantManzoor Ullah0Sultan Mehmood1Rehmat Ali Khan2Maroof Ali3Fozia Fozia4Muhammad Waqas5Riaz Ullah6Amal Alotaibi7Mujeeb A. Sultan8Department of Botany University of Science & Technology Bannu (28100) Khyber PakhtunkhwaDepartment of Botany University of Science & Technology Bannu (28100) Khyber PakhtunkhwaDepartment of Biotechnology University of Science & Technology Bannu Khyber PakhtunkhwaCollege of Life ScienceBiochemistry DepartmentDepartment of Botany University of Science & Technology Bannu (28100) Khyber PakhtunkhwaDepartment of Pharmacognosy (MAPPRC)Department of Basic ScienceDepartment of PharmacyThe traditional antidiabetic plant Viscum album (V. album) was collected from the oak plant in the wild at Maidan, Khyber District, of Pakistan, for assessment of its antidiabetic potential and phytochemical profile. Lowering of blood glucose level, antioxidant effect, lipids profile, liver function marker enzymes, and kidney function markers were evaluated in extract and glibenclamide treated groups, in normal as well as in diabetic control groups. An elevated level of blood glucose level, lipids (Cholesterol, TG, LDL), liver function marker enzymes (ALT, AST, ALP), and kidney function markers (bilirubin, creatinine, urea) were observed in alloxan-induced diabetic rats; however, a HDL level was decreased. Administration of V. album hydroalcoholic extract for 28 days renovated significantly (p<0.05) all the above biochemical parameters. The antioxidant enzymes SOD, CAT, and GPX were also considerably restored. In vitro, antioxidant assay indicated that the extract of 2,000 µg/mL scavenges free radicals of DPPH 68.4%, ABTS 69.5%, and H2O2 50.6%. The extracts revealed the presence of saponins, flavonoids, alkaloids, terpene, tannins, phenols, protein, amino acids, sterols, and glycosides. The extract has shown phenolic contents 421 ± 4.8 mg GAE/100 g d. w and flavonoids content 127 ± 1.4 mg equiv. Rut/100 g d. w. The findings of this research recommend V. album could be a potent source of natural antidiabetic constituents.http://dx.doi.org/10.1155/2022/5691379 |
| spellingShingle | Manzoor Ullah Sultan Mehmood Rehmat Ali Khan Maroof Ali Fozia Fozia Muhammad Waqas Riaz Ullah Amal Alotaibi Mujeeb A. Sultan Assessment of Antidiabetic Potential and Phytochemical Profiling of Viscum album, a Traditional Antidiabetic Plant Journal of Food Quality |
| title | Assessment of Antidiabetic Potential and Phytochemical Profiling of Viscum album, a Traditional Antidiabetic Plant |
| title_full | Assessment of Antidiabetic Potential and Phytochemical Profiling of Viscum album, a Traditional Antidiabetic Plant |
| title_fullStr | Assessment of Antidiabetic Potential and Phytochemical Profiling of Viscum album, a Traditional Antidiabetic Plant |
| title_full_unstemmed | Assessment of Antidiabetic Potential and Phytochemical Profiling of Viscum album, a Traditional Antidiabetic Plant |
| title_short | Assessment of Antidiabetic Potential and Phytochemical Profiling of Viscum album, a Traditional Antidiabetic Plant |
| title_sort | assessment of antidiabetic potential and phytochemical profiling of viscum album a traditional antidiabetic plant |
| url | http://dx.doi.org/10.1155/2022/5691379 |
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