Development of new albumin-binding radiotracers for PET imaging of cerebrospinal fluid flow in the glymphatic system

Development of new albumin-binding radiotracers for PET imaging of cerebrospinal fluid flow in the glymphatic system

Abstract Background The glymphatic system is a recently discovered brain-wide clearance system that allows the cerebrospinal fluid (CSF) flow to clear metabolic waste, but the tools for the quantitative and non-invasive investigation of its function and activity especially in humans is lacking, hind...

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Bibliographic Details
Main Authors: Martta Peltoniemi, Surachet Imlimthan, Sonja C. Jalonen, Niklas Daniel Åke Persson, Terhi J. Lohela, Tuomas O. Lilius, Mirkka Sarparanta
Format: Article
Language:English
Published: SpringerOpen 2025-07-01
Series:EJNMMI Radiopharmacy and Chemistry
Subjects:
Albumin-binding
Cerebrospinal fluid (CSF) flow
Glymphatic system
Gallium-68
Intrathecal
Positron emission tomography (PET)
Online Access:https://doi.org/10.1186/s41181-025-00365-4
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