Regulatory T cell epitope content in human antibodies decreases during maturation

Regulatory T cell epitope content in human antibodies decreases during maturation

IntroductionAntibody maturation in the lymphoid follicle produces antibodies with improved binding affinity. This process requires iterative rounds of mutation and B cell expansion, supported by T cells that recognize epitopes presented on the B cell’s MHC-II. In this comprehensive antibody repertoi...

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Bibliographic Details
Main Authors: Andres H. Gutierrez, Frances E. Terry, Amy S. Rosenberg, William D. Martin, Anne S. De Groot
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Immunology
Subjects:
B cell maturation
germinal center (GC)
somatic hypermutation (SHM)
antibody repertoire
B cell receptor (BCR)
HLA-DR T cell epitopes
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1535826/full
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