PDK4 and nutrient responses explain muscle specific manifestation in mitochondrial disease

PDK4 and nutrient responses explain muscle specific manifestation in mitochondrial disease

Abstract Background Mitochondria elicit various metabolic stress responses, the roles of which in diseases are poorly understood. Here, we explore how different muscles of one individual—extraocular muscles (EOMs) and quadriceps femoris (QFs) muscles—respond to mitochondrial disease. The aim is to e...

Full description

Saved in:
Bibliographic Details
Main Authors: Swagat Pradhan, Takayuki Mito, Nahid A Khan, Sofiia Olander, Aleksandra Zhaivoron, Thomas G McWilliams, Anu Suomalainen
Format: Article
Language:English
Published: Wiley 2025-07-01
Series:Clinical and Translational Medicine
Subjects:
progressive external ophthalmoplegia
nutrient signaling
mitochondrial disease
integrated stress response
mitochondrial myopathy
pyruvate dehydrogenase kinase
Online Access:https://doi.org/10.1002/ctm2.70404
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1002/ctm2.70404

Similar Items