Stroma-derived Dickkopf-1 contributes to the suppression of NK cell cytotoxicity in breast cancer

Stroma-derived Dickkopf-1 contributes to the suppression of NK cell cytotoxicity in breast cancer

Abstract Mechanisms related to tumor evasion from NK cell-mediated immune surveillance remain enigmatic. Dickkopf-1 (DKK1) is a Wnt/β-catenin inhibitor, whose levels correlate with breast cancer progression. We find DKK1 to be expressed by tumor cells and cancer-associated fibroblasts (CAFs) in pati...

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Main Authors: Seunghyun Lee, Biancamaria Ricci, Jennifer Tran, Emily Eul, Jiayu Ye, Qihao Ren, David Clever, Julia Wang, Pamela Wong, Michael S. Haas, Sheila A. Stewart, Cynthia X. Ma, Todd A. Fehniger, Roberta Faccio
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-56420-w
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https://doi.org/10.1038/s41467-025-56420-w

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