The highly rugged yet navigable regulatory landscape of the bacterial transcription factor TetR

Abstract Transcription factor binding sites (TFBSs) are important sources of evolutionary innovations. Understanding how evolution navigates the sequence space of such sites can be achieved by mapping TFBS adaptive landscapes. In such a landscape, an individual location corresponds to a TFBS bound b...

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Bibliographic Details
Main Authors: Cauã Antunes Westmann, Leander Goldbach, Andreas Wagner
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54723-y
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