The function of PCSK9 in doxorubicin-induced cardiotoxicity and its underlying mechanism

The function of PCSK9 in doxorubicin-induced cardiotoxicity and its underlying mechanism

Abstract Doxorubicin (DOX) is an anthracycline class of chemotherapy drug, the application of which is limited due to its cardiotoxic effects. Recombinant Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9), is a serine protease pivotal in lipid metabolism and has a profound correlation with the o...

Full description

Saved in:
Bibliographic Details
Main Authors: Shuai Shi, Zhihui Qin, Chang Liu, Yanru Zhao, Xiaopeng Bai, Chaoyu Sun, Xu Li, Wanting Cong, Xinyue Yuan, Lixiu Sun, Bingchen Liu, Xueqi Li
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Doxorubicin
PCSK9
KPNB1
Apoptosis
Cardiotoxicity
Online Access:https://doi.org/10.1038/s41598-025-03419-4
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1038/s41598-025-03419-4

Similar Items