Cardiovascular Side Effects of Atomoxetine and Its Interactions with Inhibitors of the Cytochrome P450 System
Attention deficit hyperactivity disorder (ADHD) is one of the most common neurobehavioral disorders of childhood and adolescence. Classically, stimulants have been used in the treatment of this condition. Atomoxetine (Strattera; Eli Lilly and Company) is a selective norepinephrine reuptake inhibitor...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2011/952584 |
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| author | Pashtoon Murtaza Kasi Rawad Mounzer George H. Gleeson |
| author_facet | Pashtoon Murtaza Kasi Rawad Mounzer George H. Gleeson |
| author_sort | Pashtoon Murtaza Kasi |
| collection | DOAJ |
| description | Attention deficit hyperactivity disorder (ADHD) is one of the most common neurobehavioral disorders of childhood and adolescence. Classically, stimulants have been used in the treatment of this condition. Atomoxetine (Strattera; Eli Lilly and Company) is a selective norepinephrine reuptake inhibitor (SNRI), one of the first medications in the nonstimulant class of medications that has been approved by the FDA for the treatment of ADHD. Atomoxetine is a phenoxypropylamine derivative and is structurally related to the antidepressant fluoxetine. The common side effects reported with the use of atomoxetine include mainly GI disturbances. Cardiovascular side effects are less commonly reported. The increase in the noradrenergic tone may explain some of the side effects noted with the use of this medication. Here, we present a case of a patient who presented with syncope, orthostatic hypotension, and tachycardia and discuss the various clinical implications based on the pharmacokinetics and pharmacodynamics of the drug. |
| format | Article |
| id | doaj-art-10d83f827d4449bdac4185681ab1e419 |
| institution | Kabale University |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-10d83f827d4449bdac4185681ab1e4192025-02-03T05:50:21ZengWileyCase Reports in Medicine1687-96271687-96352011-01-01201110.1155/2011/952584952584Cardiovascular Side Effects of Atomoxetine and Its Interactions with Inhibitors of the Cytochrome P450 SystemPashtoon Murtaza Kasi0Rawad Mounzer1George H. Gleeson2PGY1, International Scholars Program, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USAPGY3, International Scholars Program, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USAUniversity of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USAAttention deficit hyperactivity disorder (ADHD) is one of the most common neurobehavioral disorders of childhood and adolescence. Classically, stimulants have been used in the treatment of this condition. Atomoxetine (Strattera; Eli Lilly and Company) is a selective norepinephrine reuptake inhibitor (SNRI), one of the first medications in the nonstimulant class of medications that has been approved by the FDA for the treatment of ADHD. Atomoxetine is a phenoxypropylamine derivative and is structurally related to the antidepressant fluoxetine. The common side effects reported with the use of atomoxetine include mainly GI disturbances. Cardiovascular side effects are less commonly reported. The increase in the noradrenergic tone may explain some of the side effects noted with the use of this medication. Here, we present a case of a patient who presented with syncope, orthostatic hypotension, and tachycardia and discuss the various clinical implications based on the pharmacokinetics and pharmacodynamics of the drug.http://dx.doi.org/10.1155/2011/952584 |
| spellingShingle | Pashtoon Murtaza Kasi Rawad Mounzer George H. Gleeson Cardiovascular Side Effects of Atomoxetine and Its Interactions with Inhibitors of the Cytochrome P450 System Case Reports in Medicine |
| title | Cardiovascular Side Effects of Atomoxetine and Its Interactions with Inhibitors of the Cytochrome P450 System |
| title_full | Cardiovascular Side Effects of Atomoxetine and Its Interactions with Inhibitors of the Cytochrome P450 System |
| title_fullStr | Cardiovascular Side Effects of Atomoxetine and Its Interactions with Inhibitors of the Cytochrome P450 System |
| title_full_unstemmed | Cardiovascular Side Effects of Atomoxetine and Its Interactions with Inhibitors of the Cytochrome P450 System |
| title_short | Cardiovascular Side Effects of Atomoxetine and Its Interactions with Inhibitors of the Cytochrome P450 System |
| title_sort | cardiovascular side effects of atomoxetine and its interactions with inhibitors of the cytochrome p450 system |
| url | http://dx.doi.org/10.1155/2011/952584 |
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