Diethylcarbamazine Reduces Chronic Inflammation and Fibrosis in Carbon Tetrachloride- (CCl4-) Induced Liver Injury in Mice

Diethylcarbamazine Reduces Chronic Inflammation and Fibrosis in Carbon Tetrachloride- (CCl4-) Induced Liver Injury in Mice

This study investigated the anti-inflammatory effects of DEC on the CCl4-induced hepatotoxicity in C57BL/6 mice. Chronic inflammation was induced by i.p. administration of CCl4 0.5 μL/g of body weight through two injections a week for 6 weeks. DEC (50 mg/kg) was administered by gavage for 12 days be...

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Main Authors: Sura Wanessa Santos Rocha, Maria Eduarda Rocha de França, Gabriel Barros Rodrigues, Karla Patrícia Sousa Barbosa, Ana Karolina Santana Nunes, André Filipe Pastor, Anne Gabrielle Vasconcelos Oliveira, Wilma Helena Oliveira, Rayana Leal Almeida Luna, Christina Alves Peixoto
Format: Article
Language:English
Published: Wiley 2014-01-01
Series:Mediators of Inflammation
Online Access:http://dx.doi.org/10.1155/2014/696383
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http://dx.doi.org/10.1155/2014/696383

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