Molecular principles of redox-coupled sodium pumping of the ancient Rnf machinery

Molecular principles of redox-coupled sodium pumping of the ancient Rnf machinery

Abstract The Rnf complex is the primary respiratory enzyme of several anaerobic prokaryotes that transfers electrons from ferredoxin to NAD+ and pumps ions (Na+ or H+) across a membrane, powering ATP synthesis. Rnf is widespread in primordial organisms and the evolutionary predecessor of the Na+-pum...

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Main Authors: Anuj Kumar, Jennifer Roth, Hyunho Kim, Patricia Saura, Stefan Bohn, Tristan Reif-Trauttmansdorff, Anja Schubert, Ville R. I. Kaila, Jan M. Schuller, Volker Müller
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-57375-8
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https://doi.org/10.1038/s41467-025-57375-8

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