Modulation of glucocorticoid receptor function under iron overload

Modulation of glucocorticoid receptor function under iron overload

Acute iron overload leads to ferroptosis, in a mouse model of FeSO4 challenge causing lethal shock, associated with inflammation and multiple organ failure (MOF). We investigated molecular aspects causing this phenomenon upon FeSO4 overload, with a focus on the glucocorticoid receptor (GR), an impor...

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Bibliographic Details
Main Authors: Wanting Zhu, Tineke Vanderhaeghen, Steven Timmermans, Jolien Vandewalle, Melanie Eggermont, Nicolette J. D. Verhoog, Claude Libert
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
iron
glucocorticoids
ferroptosis
function
critical illnesses
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1605420/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1605420/full

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