Optimal Treatment for Intermediate- and High-Risk, Nonmuscle-Invasive Bladder Cancer
According to clinical and pathological factors the prognosis of a patient with non-muscle invasive bladder tumors can be assessed. The prognosis is determined by the likelihood of recurrence(30-70%) and/or progression to muscle invasive bladder cancer(1-15%).Trans urethral resection of bladder tum...
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| Format: | Article |
| Language: | English |
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Wiley
2006-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2006.403 |
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| _version_ | 1832549838373257216 |
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| author | A.P.M. van der Meijden |
| author_facet | A.P.M. van der Meijden |
| author_sort | A.P.M. van der Meijden |
| collection | DOAJ |
| description | According to clinical and pathological factors the prognosis of a patient with non-muscle invasive bladder tumors can be assessed. The prognosis is determined by the likelihood of recurrence(30-70%) and/or progression to muscle invasive bladder cancer(1-15%).Trans urethral resection of bladder tumors remains the initial therapy but adjuvant intravesical instillations are necessary.All patients benefit from a single immediate post operative instillation with a chemotherapeutic agent and for low risk tumors this is the optimal therapy.Patients with intermediate and high risk tumors need more intravesical chemo-or immunotherapy. Chemotherapy reduces recurrences but not progression. Intravesical immunotherapy(BCG) prevents or delays progression. Patients at high risk for progression may need upfront cystectomy. |
| format | Article |
| id | doaj-art-0fa4acb1e98544ecbf6a85fe07060a1e |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2006-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-0fa4acb1e98544ecbf6a85fe07060a1e2025-02-03T06:08:18ZengWileyThe Scientific World Journal1537-744X2006-01-0162611261610.1100/tsw.2006.403Optimal Treatment for Intermediate- and High-Risk, Nonmuscle-Invasive Bladder CancerA.P.M. van der Meijden0Department of Urology, Jeroen Bosch Hospital, 5200 ME 's-Hertogenbosch, The NetherlandsAccording to clinical and pathological factors the prognosis of a patient with non-muscle invasive bladder tumors can be assessed. The prognosis is determined by the likelihood of recurrence(30-70%) and/or progression to muscle invasive bladder cancer(1-15%).Trans urethral resection of bladder tumors remains the initial therapy but adjuvant intravesical instillations are necessary.All patients benefit from a single immediate post operative instillation with a chemotherapeutic agent and for low risk tumors this is the optimal therapy.Patients with intermediate and high risk tumors need more intravesical chemo-or immunotherapy. Chemotherapy reduces recurrences but not progression. Intravesical immunotherapy(BCG) prevents or delays progression. Patients at high risk for progression may need upfront cystectomy.http://dx.doi.org/10.1100/tsw.2006.403 |
| spellingShingle | A.P.M. van der Meijden Optimal Treatment for Intermediate- and High-Risk, Nonmuscle-Invasive Bladder Cancer The Scientific World Journal |
| title | Optimal Treatment for Intermediate- and High-Risk, Nonmuscle-Invasive Bladder Cancer |
| title_full | Optimal Treatment for Intermediate- and High-Risk, Nonmuscle-Invasive Bladder Cancer |
| title_fullStr | Optimal Treatment for Intermediate- and High-Risk, Nonmuscle-Invasive Bladder Cancer |
| title_full_unstemmed | Optimal Treatment for Intermediate- and High-Risk, Nonmuscle-Invasive Bladder Cancer |
| title_short | Optimal Treatment for Intermediate- and High-Risk, Nonmuscle-Invasive Bladder Cancer |
| title_sort | optimal treatment for intermediate and high risk nonmuscle invasive bladder cancer |
| url | http://dx.doi.org/10.1100/tsw.2006.403 |
| work_keys_str_mv | AT apmvandermeijden optimaltreatmentforintermediateandhighrisknonmuscleinvasivebladdercancer |