Targeting Replication Fork Processing Synergizes with PARP Inhibition to Potentiate Lethality in Homologous Recombination Proficient Ovarian Cancers

Targeting Replication Fork Processing Synergizes with PARP Inhibition to Potentiate Lethality in Homologous Recombination Proficient Ovarian Cancers

Abstract Synthetic lethality in homologous recombination (HR)‐deficient cancers caused by Poly (ADP‐ribose) polymerase inhibitors (PARPi) has been classically attributed to its role in DNA repair. The mode of action of PARPi and resistance thereof are now believed to be predominantly replication ass...

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Main Authors: Ganesh Pai Bellare, Kshama Kundu, Papiya Dey, Krupa Thankam Philip, Nitish Chauhan, Muskan Sharma, Sankarsingh Kesharsingh Rajput, Birija Sankar Patro
Format: Article
Language:English
Published: Wiley 2025-05-01
Series:Advanced Science
Subjects:
trans‐4,4′‐dihydroxystilbene (DHS)
DNA replication
PARP inhibitor
ssDNA gaps
talazoparib
Online Access:https://doi.org/10.1002/advs.202410718
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https://doi.org/10.1002/advs.202410718

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