Maternal Characteristics of Women Exposed to Hypnotic Benzodiazepine Receptor Agonist during Pregnancy
Background. There is little knowledge regarding the characteristics of women treated with hypnotic benzodiazepine receptor agonists (HBRAs) during pregnancy. In this large Danish cohort study, we characterize women exposed to HBRA during pregnancy. We determined changes in prevalence of HBRA use fro...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2014-01-01
|
| Series: | Obstetrics and Gynecology International |
| Online Access: | http://dx.doi.org/10.1155/2014/945621 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832551718888407040 |
|---|---|
| author | Bjarke Askaa Espen Jimenez-Solem Henrik Enghusen Poulsen Jon Traerup Andersen |
| author_facet | Bjarke Askaa Espen Jimenez-Solem Henrik Enghusen Poulsen Jon Traerup Andersen |
| author_sort | Bjarke Askaa |
| collection | DOAJ |
| description | Background. There is little knowledge regarding the characteristics of women treated with hypnotic benzodiazepine receptor agonists (HBRAs) during pregnancy. In this large Danish cohort study, we characterize women exposed to HBRA during pregnancy. We determined changes in prevalence of HBRA use from 1997 to 2010 and exposure to HBRAs in relation to pregnancy. Methods. We performed a retrospective cohort study including 911,017 pregnant women in the period from 1997 to 2010. Information was retrieved from The Danish Birth Registry and The Registry of Medicinal Product Statistics to identify pregnant women redeeming a prescription of HBRAs. Results. We identified 2,552 women exposed to HBRAs during pregnancy, increasing from 0.18% in 1997 to 0.23% in 2010. Compared to unexposed women, exposed women were characterized by being older, with higher BMI, in their third or fourth parity, of lower income and education level, more frequently smokers, and more likely to be comedicated with antipsychotic, anxiolytic, or antidepressant drugs (P<0.0001). Conclusion. Women using HBRAs during their pregnancy differ from unexposed women in socioeconomic factors and were more likely to receive comedication. The consumption of HBRAs was reduced during pregnancy compared to before conception. |
| format | Article |
| id | doaj-art-0efdf625263549b2aa9624da07e6e18f |
| institution | Kabale University |
| issn | 1687-9589 1687-9597 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Obstetrics and Gynecology International |
| spelling | doaj-art-0efdf625263549b2aa9624da07e6e18f2025-02-03T06:00:44ZengWileyObstetrics and Gynecology International1687-95891687-95972014-01-01201410.1155/2014/945621945621Maternal Characteristics of Women Exposed to Hypnotic Benzodiazepine Receptor Agonist during PregnancyBjarke Askaa0Espen Jimenez-Solem1Henrik Enghusen Poulsen2Jon Traerup Andersen3Department of Clinical Pharmacology, Bispebjerg Hospital, Bispebjerg Bakke 23, 2400 Copenhagen, DenmarkDepartment of Clinical Pharmacology, Bispebjerg Hospital, Bispebjerg Bakke 23, 2400 Copenhagen, DenmarkDepartment of Clinical Pharmacology, Bispebjerg Hospital, Bispebjerg Bakke 23, 2400 Copenhagen, DenmarkDepartment of Clinical Pharmacology, Bispebjerg Hospital, Bispebjerg Bakke 23, 2400 Copenhagen, DenmarkBackground. There is little knowledge regarding the characteristics of women treated with hypnotic benzodiazepine receptor agonists (HBRAs) during pregnancy. In this large Danish cohort study, we characterize women exposed to HBRA during pregnancy. We determined changes in prevalence of HBRA use from 1997 to 2010 and exposure to HBRAs in relation to pregnancy. Methods. We performed a retrospective cohort study including 911,017 pregnant women in the period from 1997 to 2010. Information was retrieved from The Danish Birth Registry and The Registry of Medicinal Product Statistics to identify pregnant women redeeming a prescription of HBRAs. Results. We identified 2,552 women exposed to HBRAs during pregnancy, increasing from 0.18% in 1997 to 0.23% in 2010. Compared to unexposed women, exposed women were characterized by being older, with higher BMI, in their third or fourth parity, of lower income and education level, more frequently smokers, and more likely to be comedicated with antipsychotic, anxiolytic, or antidepressant drugs (P<0.0001). Conclusion. Women using HBRAs during their pregnancy differ from unexposed women in socioeconomic factors and were more likely to receive comedication. The consumption of HBRAs was reduced during pregnancy compared to before conception.http://dx.doi.org/10.1155/2014/945621 |
| spellingShingle | Bjarke Askaa Espen Jimenez-Solem Henrik Enghusen Poulsen Jon Traerup Andersen Maternal Characteristics of Women Exposed to Hypnotic Benzodiazepine Receptor Agonist during Pregnancy Obstetrics and Gynecology International |
| title | Maternal Characteristics of Women Exposed to Hypnotic Benzodiazepine Receptor Agonist during Pregnancy |
| title_full | Maternal Characteristics of Women Exposed to Hypnotic Benzodiazepine Receptor Agonist during Pregnancy |
| title_fullStr | Maternal Characteristics of Women Exposed to Hypnotic Benzodiazepine Receptor Agonist during Pregnancy |
| title_full_unstemmed | Maternal Characteristics of Women Exposed to Hypnotic Benzodiazepine Receptor Agonist during Pregnancy |
| title_short | Maternal Characteristics of Women Exposed to Hypnotic Benzodiazepine Receptor Agonist during Pregnancy |
| title_sort | maternal characteristics of women exposed to hypnotic benzodiazepine receptor agonist during pregnancy |
| url | http://dx.doi.org/10.1155/2014/945621 |
| work_keys_str_mv | AT bjarkeaskaa maternalcharacteristicsofwomenexposedtohypnoticbenzodiazepinereceptoragonistduringpregnancy AT espenjimenezsolem maternalcharacteristicsofwomenexposedtohypnoticbenzodiazepinereceptoragonistduringpregnancy AT henrikenghusenpoulsen maternalcharacteristicsofwomenexposedtohypnoticbenzodiazepinereceptoragonistduringpregnancy AT jontraerupandersen maternalcharacteristicsofwomenexposedtohypnoticbenzodiazepinereceptoragonistduringpregnancy |