MurG as a potential target of quercetin in Staphylococcus aureus supported by evidence from subtractive proteomics and molecular dynamics

MurG as a potential target of quercetin in Staphylococcus aureus supported by evidence from subtractive proteomics and molecular dynamics

Abstract The rise of methicillin-resistant Staphylococcus aureus (MRSA) as a major public health threat underscores a critical need for new antibacterial strategies. Quercetin is a naturally occurring flavonoid with a range of bioactivities, including antibacterial activity against S. aureus. Howeve...

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Bibliographic Details
Main Authors: Dweipayan Goswami, Jignesh Prajapati, Milan Dabhi, Liam K. R. Sharkey, Sacha J. Pidot
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Subjects:
Quercetin
MRSA
MurG
Glycosyltransferase
Molecular dynamics (MD) simulations
Subtractive proteomics approach
Online Access:https://doi.org/10.1038/s41598-025-90395-4
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https://doi.org/10.1038/s41598-025-90395-4

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