A novel synthetic synovial fluid model for investigating biofilm formation and antibiotic susceptibility in prosthetic joint infections

A novel synthetic synovial fluid model for investigating biofilm formation and antibiotic susceptibility in prosthetic joint infections

ABSTRACT There is growing evidence that bacteria encountered in prosthetic joint infections (PJIs) form surface-attached biofilms on prostheses, as well as biofilm aggregates embedded in synovial fluid and tissues. However, in vitro models allowing the investigation of these biofilms and the assessm...

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Main Authors: Amber De Bleeckere, Frits van Charante, Thibault Debord, Stien Vandendriessche, Michiel De Cock, Marte Verstraete, Fabien Lamret, Bram Lories, Jerina Boelens, Fany Reffuveille, Hans P. Steenackers, Tom Coenye
Format: Article
Language:English
Published: American Society for Microbiology 2025-01-01
Series:Microbiology Spectrum
Subjects:
prosthetic joint infection
synovial fluid
biofilms
Online Access:https://journals.asm.org/doi/10.1128/spectrum.01980-24
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https://journals.asm.org/doi/10.1128/spectrum.01980-24

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