Grepafloxacin Clinical Program for Lower Respiratory Tract Infections
The present paper evaluates the clinical trial program in lower respiratory tract infections treated with a new fluoroquinolone antibiotic, grepafloxacin. Unlike older quinolones, grepafloxacin has excellent activity against Gram-positive organisms, which include Streptococcus pneumoniae and “atypic...
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| Format: | Article |
| Language: | English |
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Wiley
1998-01-01
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| Series: | Canadian Journal of Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/1998/762368 |
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| _version_ | 1832559119191506944 |
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| author | Arne C Rodloff |
| author_facet | Arne C Rodloff |
| author_sort | Arne C Rodloff |
| collection | DOAJ |
| description | The present paper evaluates the clinical trial program in lower respiratory tract infections treated with a new fluoroquinolone antibiotic, grepafloxacin. Unlike older quinolones, grepafloxacin has excellent activity against Gram-positive organisms, which include Streptococcus pneumoniae and “atypical” pathogens Legionella species. Mycoplasma pneumoniae and Chlamydia pneumoniae. Grepafloxacin has a long half-life of 12 to 15 h, which allows once daily dosing. Six studies have been conducted regarding community-acquired lower respiratory tract infections (LRTls), four about community-acquired pneumonia (CAP) and two about acute bacterial exacerbations of chronic bronchitis (ABECB) . In these studies, grepafloxacin demonstrated clinical equivalence with standard therapies. but, in patients with documented infections. grepafloxacin was statistically superior to amoxycillin in both CAP and ABECB. The new fluoroquinolone has a good safety profile, comparable with that of ciprofloxacin. The most common adverse effects of grepafloxacin were nausea and a metallic taste; however, these effects resulted in only a few discontinuations of therapy. With the increasing prevalence of resistance in pathogens isolated from community-acquired LRTIs, grepafloxacin offers a good alternative for monotherapy in these patients. |
| format | Article |
| id | doaj-art-0ec5bfcd1b1f41e0b5f9eb94f569d61a |
| institution | Kabale University |
| issn | 1180-2332 |
| language | English |
| publishDate | 1998-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Infectious Diseases |
| spelling | doaj-art-0ec5bfcd1b1f41e0b5f9eb94f569d61a2025-02-03T01:30:46ZengWileyCanadian Journal of Infectious Diseases1180-23321998-01-019Suppl E23E26E10.1155/1998/762368Grepafloxacin Clinical Program for Lower Respiratory Tract InfectionsArne C Rodloff0lnstitut für Medizinische Mikrobiologie, und lnfecktionsepidemiologie, der Universität Leipzig, Leipzig, GermanyThe present paper evaluates the clinical trial program in lower respiratory tract infections treated with a new fluoroquinolone antibiotic, grepafloxacin. Unlike older quinolones, grepafloxacin has excellent activity against Gram-positive organisms, which include Streptococcus pneumoniae and “atypical” pathogens Legionella species. Mycoplasma pneumoniae and Chlamydia pneumoniae. Grepafloxacin has a long half-life of 12 to 15 h, which allows once daily dosing. Six studies have been conducted regarding community-acquired lower respiratory tract infections (LRTls), four about community-acquired pneumonia (CAP) and two about acute bacterial exacerbations of chronic bronchitis (ABECB) . In these studies, grepafloxacin demonstrated clinical equivalence with standard therapies. but, in patients with documented infections. grepafloxacin was statistically superior to amoxycillin in both CAP and ABECB. The new fluoroquinolone has a good safety profile, comparable with that of ciprofloxacin. The most common adverse effects of grepafloxacin were nausea and a metallic taste; however, these effects resulted in only a few discontinuations of therapy. With the increasing prevalence of resistance in pathogens isolated from community-acquired LRTIs, grepafloxacin offers a good alternative for monotherapy in these patients.http://dx.doi.org/10.1155/1998/762368 |
| spellingShingle | Arne C Rodloff Grepafloxacin Clinical Program for Lower Respiratory Tract Infections Canadian Journal of Infectious Diseases |
| title | Grepafloxacin Clinical Program for Lower Respiratory Tract Infections |
| title_full | Grepafloxacin Clinical Program for Lower Respiratory Tract Infections |
| title_fullStr | Grepafloxacin Clinical Program for Lower Respiratory Tract Infections |
| title_full_unstemmed | Grepafloxacin Clinical Program for Lower Respiratory Tract Infections |
| title_short | Grepafloxacin Clinical Program for Lower Respiratory Tract Infections |
| title_sort | grepafloxacin clinical program for lower respiratory tract infections |
| url | http://dx.doi.org/10.1155/1998/762368 |
| work_keys_str_mv | AT arnecrodloff grepafloxacinclinicalprogramforlowerrespiratorytractinfections |