Silent protocol modifications in multiple sclerosis clinical trials: a registry-based cross-sectional study

Background: Changes in the original protocol of clinical trials should be clearly declared to the readers of journal publications. Otherwise, they can lead to selective outcome reporting bias or distort the appropriate judgement of the study’s external validity and statistical power, among other pro...

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Main Authors: Alejandro Rivero-de-Aguilar, Mónica Pérez-Ríos, Joseph S. Ross, Marta Mascareñas-García, Alberto Ruano-Raviña, Marilina Puente-Hernandez, Leonor Varela-Lema
Format: Article
Language:English
Published: SAGE Publishing 2025-06-01
Series:Therapeutic Advances in Neurological Disorders
Online Access:https://doi.org/10.1177/17562864251335247
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