Posterior Mediastinal Adenomatoid Tumor: A Case Report and Review of the Literature
Adenomatoid tumor is an uncommon benign neoplasm of mesothelial differentiation that distinctively arises in and around the genital organs. In rare instances, it has been described in extragenital locations. There have been only two reports documenting its occurrence in the anterior mediastinum, and...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Case Reports in Pathology |
| Online Access: | http://dx.doi.org/10.1155/2016/6898526 |
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| author | Vishwas Parekh Thomas Winokur Robert J. Cerfolio Todd M. Stevens |
| author_facet | Vishwas Parekh Thomas Winokur Robert J. Cerfolio Todd M. Stevens |
| author_sort | Vishwas Parekh |
| collection | DOAJ |
| description | Adenomatoid tumor is an uncommon benign neoplasm of mesothelial differentiation that distinctively arises in and around the genital organs. In rare instances, it has been described in extragenital locations. There have been only two reports documenting its occurrence in the anterior mediastinum, and no reports documenting its occurrence in the posterior mediastinum. We report the first case of posterior mediastinal adenomatoid tumor. A 37-year-old Caucasian woman presented with symptoms of bronchitis. Imaging studies identified a 2.0 cm posterior mediastinal mass abutting the T9 vertebral body, clinically and radiologically most consistent with schwannoma. Histologic sections revealed a lesion composed of epithelioid cells arranged in cords and luminal profiles embedded in a fibrotic to loose stroma and surrounded by a fibrous pseudocapsule. Lesional cells showed vacuolated eosinophilic cytoplasm and peripherally displaced nuclei with prominent nucleoli. There was focal cytologic atypia but no mitotic figures or necrosis was identified. The lesional cells expressed cytokeratin, calretinin, and nuclear WT1 but were negative for PAX8, TTF1, p53, chromogranin, CD31, and CD34, and Ki67 showed <2% proliferation rate, diagnostic of adenomatoid tumor. Three years after resection, the patient is in good health without tumor recurrence. Thus, our encounter effectively expands the differential diagnosis of posterior mediastinal neoplastic entities. |
| format | Article |
| id | doaj-art-0e8c6e8e2cd54accb583fed9f77fc77c |
| institution | Kabale University |
| issn | 2090-6781 2090-679X |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pathology |
| spelling | doaj-art-0e8c6e8e2cd54accb583fed9f77fc77c2025-02-03T05:59:12ZengWileyCase Reports in Pathology2090-67812090-679X2016-01-01201610.1155/2016/68985266898526Posterior Mediastinal Adenomatoid Tumor: A Case Report and Review of the LiteratureVishwas Parekh0Thomas Winokur1Robert J. Cerfolio2Todd M. Stevens3Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35249, USADepartment of Pathology, University of Alabama at Birmingham, Birmingham, AL 35249, USADepartment of Surgery, University of Alabama at Birmingham, Birmingham, AL 35249, USADepartment of Pathology, University of Alabama at Birmingham, Birmingham, AL 35249, USAAdenomatoid tumor is an uncommon benign neoplasm of mesothelial differentiation that distinctively arises in and around the genital organs. In rare instances, it has been described in extragenital locations. There have been only two reports documenting its occurrence in the anterior mediastinum, and no reports documenting its occurrence in the posterior mediastinum. We report the first case of posterior mediastinal adenomatoid tumor. A 37-year-old Caucasian woman presented with symptoms of bronchitis. Imaging studies identified a 2.0 cm posterior mediastinal mass abutting the T9 vertebral body, clinically and radiologically most consistent with schwannoma. Histologic sections revealed a lesion composed of epithelioid cells arranged in cords and luminal profiles embedded in a fibrotic to loose stroma and surrounded by a fibrous pseudocapsule. Lesional cells showed vacuolated eosinophilic cytoplasm and peripherally displaced nuclei with prominent nucleoli. There was focal cytologic atypia but no mitotic figures or necrosis was identified. The lesional cells expressed cytokeratin, calretinin, and nuclear WT1 but were negative for PAX8, TTF1, p53, chromogranin, CD31, and CD34, and Ki67 showed <2% proliferation rate, diagnostic of adenomatoid tumor. Three years after resection, the patient is in good health without tumor recurrence. Thus, our encounter effectively expands the differential diagnosis of posterior mediastinal neoplastic entities.http://dx.doi.org/10.1155/2016/6898526 |
| spellingShingle | Vishwas Parekh Thomas Winokur Robert J. Cerfolio Todd M. Stevens Posterior Mediastinal Adenomatoid Tumor: A Case Report and Review of the Literature Case Reports in Pathology |
| title | Posterior Mediastinal Adenomatoid Tumor: A Case Report and Review of the Literature |
| title_full | Posterior Mediastinal Adenomatoid Tumor: A Case Report and Review of the Literature |
| title_fullStr | Posterior Mediastinal Adenomatoid Tumor: A Case Report and Review of the Literature |
| title_full_unstemmed | Posterior Mediastinal Adenomatoid Tumor: A Case Report and Review of the Literature |
| title_short | Posterior Mediastinal Adenomatoid Tumor: A Case Report and Review of the Literature |
| title_sort | posterior mediastinal adenomatoid tumor a case report and review of the literature |
| url | http://dx.doi.org/10.1155/2016/6898526 |
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