Inhibition of Corneal Neovascularization by Topical and Subconjunctival Tigecycline
Objective. To investigate the effects of topical and subconjunctival tigecycline on the prevention of corneal neovascularization. Materials and Methods. Following chemical burn, thirty-two rats were treated daily with topical instillation of 1 mg/mL tigecycline (group 1) or subconjunctival instillat...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2014/452685 |
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| author | Sertan Goktas Ender Erdogan Rabia Sakarya Yasar Sakarya Mustafa Yılmaz Muammer Ozcimen Nejat Unlukal Ismail Alpfidan Fatih Tas Erkan Erdogan Abdulkadir Bukus Ismail Senol Ivacık |
| author_facet | Sertan Goktas Ender Erdogan Rabia Sakarya Yasar Sakarya Mustafa Yılmaz Muammer Ozcimen Nejat Unlukal Ismail Alpfidan Fatih Tas Erkan Erdogan Abdulkadir Bukus Ismail Senol Ivacık |
| author_sort | Sertan Goktas |
| collection | DOAJ |
| description | Objective. To investigate the effects of topical and subconjunctival tigecycline on the prevention of corneal neovascularization. Materials and Methods. Following chemical burn, thirty-two rats were treated daily with topical instillation of 1 mg/mL tigecycline (group 1) or subconjunctival instillation of 1 mg/mL tigecycline (group 3) for 7 days. Control rats received topical (group 2) or subconjunctival (group 4) 0.9% saline. Digital photographs of the cornea were taken on the eighth day after treatment and analyzed to determine the percentage area of the cornea covered by neovascularization. Corneal sections were analyzed histopathologically. Results. The median percentages of corneal neovascularization in groups 1 and 3 were 48% (95% confidence interval (CI), 44.2–55.8%) and 33.5% (95% CI, 26.6–39.2%), respectively. The median percentages of corneal neovascularization of groups 1 and 3 were significantly lower than that of the control group (P=0.03 and P<0.001, resp.). Histologic examination of samples from groups 1 and 3 showed lower vascularity than that of control groups. Conclusion. Topical and subconjunctival administration of tigecycline seems to be showing promising therapeutic effects on the prevention of corneal neovascularization. Furthermore, subconjunctival administration of tigecycline is more potent than topical administration in the inhibition of corneal neovascularization. |
| format | Article |
| id | doaj-art-0e563a8c2c2f47a6b1e0e7fef26a3010 |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-0e563a8c2c2f47a6b1e0e7fef26a30102025-02-03T01:03:12ZengWileyJournal of Ophthalmology2090-004X2090-00582014-01-01201410.1155/2014/452685452685Inhibition of Corneal Neovascularization by Topical and Subconjunctival TigecyclineSertan Goktas0Ender Erdogan1Rabia Sakarya2Yasar Sakarya3Mustafa Yılmaz4Muammer Ozcimen5Nejat Unlukal6Ismail Alpfidan7Fatih Tas8Erkan Erdogan9Abdulkadir Bukus10Ismail Senol Ivacık11Department of Ophthalmology, Konya Training and Research Hospital, Meram, 42090 Konya, TurkeyDepartment of Histology and Embryology, Selcuk University, 42030 Konya, TurkeyDepartment of Ophthalmology, Konya Training and Research Hospital, Meram, 42090 Konya, TurkeyDepartment of Ophthalmology, Konya Training and Research Hospital, Meram, 42090 Konya, TurkeyDepartment of Histology and Embryology, Selcuk University, 42030 Konya, TurkeyDepartment of Ophthalmology, Konya Training and Research Hospital, Meram, 42090 Konya, TurkeyDepartment of Histology and Embryology, Selcuk University, 42030 Konya, TurkeyDepartment of Ophthalmology, Konya Training and Research Hospital, Meram, 42090 Konya, TurkeyDepartment of Histology and Embryology, Mevlana University, 42030 Konya, TurkeyDepartment of Ophthalmology, Konya Training and Research Hospital, Meram, 42090 Konya, TurkeyDepartment of Ophthalmology, Konya Training and Research Hospital, Meram, 42090 Konya, TurkeyDepartment of Ophthalmology, Konya Training and Research Hospital, Meram, 42090 Konya, TurkeyObjective. To investigate the effects of topical and subconjunctival tigecycline on the prevention of corneal neovascularization. Materials and Methods. Following chemical burn, thirty-two rats were treated daily with topical instillation of 1 mg/mL tigecycline (group 1) or subconjunctival instillation of 1 mg/mL tigecycline (group 3) for 7 days. Control rats received topical (group 2) or subconjunctival (group 4) 0.9% saline. Digital photographs of the cornea were taken on the eighth day after treatment and analyzed to determine the percentage area of the cornea covered by neovascularization. Corneal sections were analyzed histopathologically. Results. The median percentages of corneal neovascularization in groups 1 and 3 were 48% (95% confidence interval (CI), 44.2–55.8%) and 33.5% (95% CI, 26.6–39.2%), respectively. The median percentages of corneal neovascularization of groups 1 and 3 were significantly lower than that of the control group (P=0.03 and P<0.001, resp.). Histologic examination of samples from groups 1 and 3 showed lower vascularity than that of control groups. Conclusion. Topical and subconjunctival administration of tigecycline seems to be showing promising therapeutic effects on the prevention of corneal neovascularization. Furthermore, subconjunctival administration of tigecycline is more potent than topical administration in the inhibition of corneal neovascularization.http://dx.doi.org/10.1155/2014/452685 |
| spellingShingle | Sertan Goktas Ender Erdogan Rabia Sakarya Yasar Sakarya Mustafa Yılmaz Muammer Ozcimen Nejat Unlukal Ismail Alpfidan Fatih Tas Erkan Erdogan Abdulkadir Bukus Ismail Senol Ivacık Inhibition of Corneal Neovascularization by Topical and Subconjunctival Tigecycline Journal of Ophthalmology |
| title | Inhibition of Corneal Neovascularization by Topical and Subconjunctival Tigecycline |
| title_full | Inhibition of Corneal Neovascularization by Topical and Subconjunctival Tigecycline |
| title_fullStr | Inhibition of Corneal Neovascularization by Topical and Subconjunctival Tigecycline |
| title_full_unstemmed | Inhibition of Corneal Neovascularization by Topical and Subconjunctival Tigecycline |
| title_short | Inhibition of Corneal Neovascularization by Topical and Subconjunctival Tigecycline |
| title_sort | inhibition of corneal neovascularization by topical and subconjunctival tigecycline |
| url | http://dx.doi.org/10.1155/2014/452685 |
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