Platelet-rich plasma combined with isometric quadriceps contraction regulates autophagy in chondrocytes via the PI3K/AKT/mTOR pathway to promote cartilage repair in knee osteoarthritis

Platelet-rich plasma combined with isometric quadriceps contraction regulates autophagy in chondrocytes via the PI3K/AKT/mTOR pathway to promote cartilage repair in knee osteoarthritis

Background: This study investigated the molecular mechanism by which the combination of platelet-rich plasma (PRP) and isometric contraction of the quadriceps (ICQ) intervention regulates autophagy in chondrocytes to prevent and treat knee osteoarthritis (KOA). Methods: Thirty Sprague-Dawley rats we...

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Bibliographic Details
Main Authors: Liang Cheng, Shuwan Chang, Yajun Tan, Benxiang He
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Regenerative Therapy
Subjects:
Platelet-rich plasm
Isometric contraction of quadricep
Autophagy
PI3K/AKT/mTOR
Knee Osteoarthritis
Online Access:http://www.sciencedirect.com/science/article/pii/S2352320424002062
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http://www.sciencedirect.com/science/article/pii/S2352320424002062

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