Synthesis, Computational Studies and Preliminary Pharmacological Evaluation of New Arylpiperazines
A series of novel arylpiperazines were synthesized and the target compounds evaluated for atypical antipsychotic activity in apomorphine induced climbing behavior (D2 antagonism), 5-HTP induced head twitches (5-HT2A antagonism) and catalepsy studies in albino mice. The physicochemical similarity of...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2011-01-01
|
| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2011/346087 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832549909547450368 |
|---|---|
| author | Sushil Kumar A. K. Wahi Ranjit Singh |
| author_facet | Sushil Kumar A. K. Wahi Ranjit Singh |
| author_sort | Sushil Kumar |
| collection | DOAJ |
| description | A series of novel arylpiperazines were synthesized and the target compounds evaluated for atypical antipsychotic activity in apomorphine induced climbing behavior (D2 antagonism), 5-HTP induced head twitches (5-HT2A antagonism) and catalepsy studies in albino mice. The physicochemical similarity of the target compounds with respect to standard drugs clozapine, ketanserine and risperidone was assessed by calculating from a set of physiochemical properties using software programs. The test compounds (3a-j) demonstrated good similarity values with respect to the standard drugs. Among them, compound 3d has emerged as an important lead compound showing potential atypical antipsychotic like profile. |
| format | Article |
| id | doaj-art-0e2f83c190d44dd796f68b74326d4c50 |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-0e2f83c190d44dd796f68b74326d4c502025-02-03T06:08:14ZengWileyE-Journal of Chemistry0973-49452090-98102011-01-01831044105110.1155/2011/346087Synthesis, Computational Studies and Preliminary Pharmacological Evaluation of New ArylpiperazinesSushil Kumar0A. K. Wahi1Ranjit Singh2Drug Design & Medicinal Chemistry Research Laboratory, College of Pharmacy, IFTM, Moradabad-244001, IndiaDrug Design & Medicinal Chemistry Research Laboratory, College of Pharmacy, IFTM, Moradabad-244001, IndiaSchool of Pharmaceutical Sciences, Shobhit University, Meerut, IndiaA series of novel arylpiperazines were synthesized and the target compounds evaluated for atypical antipsychotic activity in apomorphine induced climbing behavior (D2 antagonism), 5-HTP induced head twitches (5-HT2A antagonism) and catalepsy studies in albino mice. The physicochemical similarity of the target compounds with respect to standard drugs clozapine, ketanserine and risperidone was assessed by calculating from a set of physiochemical properties using software programs. The test compounds (3a-j) demonstrated good similarity values with respect to the standard drugs. Among them, compound 3d has emerged as an important lead compound showing potential atypical antipsychotic like profile.http://dx.doi.org/10.1155/2011/346087 |
| spellingShingle | Sushil Kumar A. K. Wahi Ranjit Singh Synthesis, Computational Studies and Preliminary Pharmacological Evaluation of New Arylpiperazines E-Journal of Chemistry |
| title | Synthesis, Computational Studies and Preliminary Pharmacological Evaluation of New Arylpiperazines |
| title_full | Synthesis, Computational Studies and Preliminary Pharmacological Evaluation of New Arylpiperazines |
| title_fullStr | Synthesis, Computational Studies and Preliminary Pharmacological Evaluation of New Arylpiperazines |
| title_full_unstemmed | Synthesis, Computational Studies and Preliminary Pharmacological Evaluation of New Arylpiperazines |
| title_short | Synthesis, Computational Studies and Preliminary Pharmacological Evaluation of New Arylpiperazines |
| title_sort | synthesis computational studies and preliminary pharmacological evaluation of new arylpiperazines |
| url | http://dx.doi.org/10.1155/2011/346087 |
| work_keys_str_mv | AT sushilkumar synthesiscomputationalstudiesandpreliminarypharmacologicalevaluationofnewarylpiperazines AT akwahi synthesiscomputationalstudiesandpreliminarypharmacologicalevaluationofnewarylpiperazines AT ranjitsingh synthesiscomputationalstudiesandpreliminarypharmacologicalevaluationofnewarylpiperazines |