The Fate of Allogeneic Pancreatic Islets following Intraportal Transplantation: Challenges and Solutions
Pancreatic islet transplantation as a therapeutic option for type 1 diabetes mellitus is gaining widespread attention because this approach can restore physiological insulin secretion, minimize the risk of hypoglycemic unawareness, and reduce the risk of death due to severe hypoglycemia. However, th...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2018/2424586 |
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| _version_ | 1832567844530814976 |
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| author | Xinyu Li Qiang Meng Lei Zhang |
| author_facet | Xinyu Li Qiang Meng Lei Zhang |
| author_sort | Xinyu Li |
| collection | DOAJ |
| description | Pancreatic islet transplantation as a therapeutic option for type 1 diabetes mellitus is gaining widespread attention because this approach can restore physiological insulin secretion, minimize the risk of hypoglycemic unawareness, and reduce the risk of death due to severe hypoglycemia. However, there are many obstacles contributing to the early mass loss of the islets and progressive islet loss in the late stages of clinical islet transplantation, including hypoxia injury, instant blood-mediated inflammatory reactions, inflammatory cytokines, immune rejection, metabolic exhaustion, and immunosuppression-related toxicity that is detrimental to the islet allograft. Here, we discuss the fate of intrahepatic islets infused through the portal vein and propose potential interventions to promote islet allograft survival and improve long-term graft function. |
| format | Article |
| id | doaj-art-0dbdf2ad31df4f02a4fe48985e5cb7db |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-0dbdf2ad31df4f02a4fe48985e5cb7db2025-02-03T01:00:24ZengWileyJournal of Immunology Research2314-88612314-71562018-01-01201810.1155/2018/24245862424586The Fate of Allogeneic Pancreatic Islets following Intraportal Transplantation: Challenges and SolutionsXinyu Li0Qiang Meng1Lei Zhang2Department of General Surgery, The 2nd Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, Harbin, 150086 Heilongjiang Province, ChinaDepartment of General Surgery, The 2nd Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, Harbin, 150086 Heilongjiang Province, ChinaDepartment of General Surgery, The 2nd Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, Harbin, 150086 Heilongjiang Province, ChinaPancreatic islet transplantation as a therapeutic option for type 1 diabetes mellitus is gaining widespread attention because this approach can restore physiological insulin secretion, minimize the risk of hypoglycemic unawareness, and reduce the risk of death due to severe hypoglycemia. However, there are many obstacles contributing to the early mass loss of the islets and progressive islet loss in the late stages of clinical islet transplantation, including hypoxia injury, instant blood-mediated inflammatory reactions, inflammatory cytokines, immune rejection, metabolic exhaustion, and immunosuppression-related toxicity that is detrimental to the islet allograft. Here, we discuss the fate of intrahepatic islets infused through the portal vein and propose potential interventions to promote islet allograft survival and improve long-term graft function.http://dx.doi.org/10.1155/2018/2424586 |
| spellingShingle | Xinyu Li Qiang Meng Lei Zhang The Fate of Allogeneic Pancreatic Islets following Intraportal Transplantation: Challenges and Solutions Journal of Immunology Research |
| title | The Fate of Allogeneic Pancreatic Islets following Intraportal Transplantation: Challenges and Solutions |
| title_full | The Fate of Allogeneic Pancreatic Islets following Intraportal Transplantation: Challenges and Solutions |
| title_fullStr | The Fate of Allogeneic Pancreatic Islets following Intraportal Transplantation: Challenges and Solutions |
| title_full_unstemmed | The Fate of Allogeneic Pancreatic Islets following Intraportal Transplantation: Challenges and Solutions |
| title_short | The Fate of Allogeneic Pancreatic Islets following Intraportal Transplantation: Challenges and Solutions |
| title_sort | fate of allogeneic pancreatic islets following intraportal transplantation challenges and solutions |
| url | http://dx.doi.org/10.1155/2018/2424586 |
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