Benefits from Long-Term Treatment in Irritable Bowel Syndrome
It is known that irritable bowel syndrome (IBS) is a chronic disease of cyclic nature characterized by recurrent symptoms. IBS patients should receive, as initial therapeutic approach a short course of treatment which, if effective, has the additional value of confirming the diagnosis. Long-term tre...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2012/936960 |
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| _version_ | 1832561889148665856 |
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| author | Stefano Evangelista |
| author_facet | Stefano Evangelista |
| author_sort | Stefano Evangelista |
| collection | DOAJ |
| description | It is known that irritable bowel syndrome (IBS) is a chronic disease of cyclic nature characterized by recurrent symptoms. IBS patients should receive, as initial therapeutic approach a short course of treatment which, if effective, has the additional value of confirming the diagnosis. Long-term treatment should be reserved to diagnosed IBS patients with recurrent symptoms. Clinical trials with stabilized therapies and new active treatments showed an improvement of the symptoms over placebo that is often time-dependent but with high relapse rates (around 40%–50% when stopping treatment). Relapse is not always immediate after stopping treatment and the recent data from OBIS trial with otilonium bromide or with psychotherapy, showed that due to different chemico-physical characteristics of the drugs or the psychosomatic impact to the disease not all treatment gave the same relapsing rate if compared to placebo. Results of IBS clinical trials with different therapies tailored to the patient needs indicate that a cyclic treatment therapy is advisable to counteract the nature of the disease. |
| format | Article |
| id | doaj-art-0da5d2d93955479f8409d68d3978f658 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-0da5d2d93955479f8409d68d3978f6582025-02-03T01:23:51ZengWileyGastroenterology Research and Practice1687-61211687-630X2012-01-01201210.1155/2012/936960936960Benefits from Long-Term Treatment in Irritable Bowel SyndromeStefano Evangelista0Department of Preclinical Development, Menarini Ricerche SpA, Via Sette Santi 1, 50131 Firenze, ItalyIt is known that irritable bowel syndrome (IBS) is a chronic disease of cyclic nature characterized by recurrent symptoms. IBS patients should receive, as initial therapeutic approach a short course of treatment which, if effective, has the additional value of confirming the diagnosis. Long-term treatment should be reserved to diagnosed IBS patients with recurrent symptoms. Clinical trials with stabilized therapies and new active treatments showed an improvement of the symptoms over placebo that is often time-dependent but with high relapse rates (around 40%–50% when stopping treatment). Relapse is not always immediate after stopping treatment and the recent data from OBIS trial with otilonium bromide or with psychotherapy, showed that due to different chemico-physical characteristics of the drugs or the psychosomatic impact to the disease not all treatment gave the same relapsing rate if compared to placebo. Results of IBS clinical trials with different therapies tailored to the patient needs indicate that a cyclic treatment therapy is advisable to counteract the nature of the disease.http://dx.doi.org/10.1155/2012/936960 |
| spellingShingle | Stefano Evangelista Benefits from Long-Term Treatment in Irritable Bowel Syndrome Gastroenterology Research and Practice |
| title | Benefits from Long-Term Treatment in Irritable Bowel Syndrome |
| title_full | Benefits from Long-Term Treatment in Irritable Bowel Syndrome |
| title_fullStr | Benefits from Long-Term Treatment in Irritable Bowel Syndrome |
| title_full_unstemmed | Benefits from Long-Term Treatment in Irritable Bowel Syndrome |
| title_short | Benefits from Long-Term Treatment in Irritable Bowel Syndrome |
| title_sort | benefits from long term treatment in irritable bowel syndrome |
| url | http://dx.doi.org/10.1155/2012/936960 |
| work_keys_str_mv | AT stefanoevangelista benefitsfromlongtermtreatmentinirritablebowelsyndrome |