Mutation T9I in Envelope confers autophagy resistance to SARS-CoV-2 Omicron

Mutation T9I in Envelope confers autophagy resistance to SARS-CoV-2 Omicron

Summary: Omicron has emerged as the most successful variant of SARS-CoV-2. In addition to mutations in Spike that mediate humoral immune escape, the Omicron-specific Envelope (E) T9I mutation has been associated with increased transmission fitness. However, the underlying mechanism remained unclear....

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Main Authors: Susanne Klute, Rayhane Nchioua, Arne Cordsmeier, Jyoti Vishwakarma, Lennart Koepke, Hala Alshammary, Christoph Jung, Maximilian Hirschenberger, Helene Hoenigsperger, Jana-Romana Fischer, Rinu Sivarajan, Fabian Zech, Steffen Stenger, Ruth Serra-Moreno, Ana Silvia Gonzalez-Reiche, Emilia Mia Sordillo, Harm van Bakel, Viviana Simon, Frank Kirchhoff, Timo Jacob, Dorota Kmiec, Andreas Pichlmair, Armin Ensser, Konstantin Maria Johannes Sparrer
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:iScience
Subjects:
Natural sciences
Biological sciences
Microbiology
Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225012350
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http://www.sciencedirect.com/science/article/pii/S2589004225012350

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