PPM1G Inhibits Epithelial–Mesenchymal Transition in Cholangiocarcinoma by Catalyzing TET1 Dephosphorylation for Destabilization to Impair Its Targeted Demethylation of the CLDN3 Promoter

PPM1G Inhibits Epithelial–Mesenchymal Transition in Cholangiocarcinoma by Catalyzing TET1 Dephosphorylation for Destabilization to Impair Its Targeted Demethylation of the CLDN3 Promoter

Abstract Ten–eleven translocation protein 1 (TET1) functions as an epigenetic regulatory molecule, mediating the majority of DNA demethylation, and plays a role in the development of different types of cancers by regulating the expression of proto‐oncogenes and oncogenes. Here it is found that TET1...

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Bibliographic Details
Main Authors: Wenzheng Liu, Yiyang Kuai, Da Wang, Junsheng Chen, Fei Xiong, Guanhua Wu, Qi Wang, Wenhua Huang, Yongqiang Qi, Bing Wang, Yongjun Chen
Format: Article
Language:English
Published: Wiley 2024-12-01
Series:Advanced Science
Subjects:
cholangiocarcinoma
demethylation
dephosphorylation
PPM1G
TET1
Online Access:https://doi.org/10.1002/advs.202407323
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https://doi.org/10.1002/advs.202407323

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