Rifabutin and Furazolidone Could Be the Candidates of the Rescue Regimen for Antibiotic-Resistant H. pylori in Korea
Background/Aim. In Korea, the rate of Helicobacter pylori (H. pylori) eradication has declined steadily as a result of increasing resistance to antibiotics, especially dual resistance to clarithromycin and metronidazole. However, microbiological culture data on drug-resistant H. pylori is lacking. T...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Canadian Journal of Infectious Diseases and Medical Microbiology |
| Online Access: | http://dx.doi.org/10.1155/2019/9351801 |
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| author | Youn I Choi Sang-Ho Jeong Jun-Won Chung Dong Kyun Park Kyoung Oh Kim Kwang An Kwon Yoon Jae Kim Seol So Jeong Hoon Lee Jin-Young Jeong Sun-Mi Lee |
| author_facet | Youn I Choi Sang-Ho Jeong Jun-Won Chung Dong Kyun Park Kyoung Oh Kim Kwang An Kwon Yoon Jae Kim Seol So Jeong Hoon Lee Jin-Young Jeong Sun-Mi Lee |
| author_sort | Youn I Choi |
| collection | DOAJ |
| description | Background/Aim. In Korea, the rate of Helicobacter pylori (H. pylori) eradication has declined steadily as a result of increasing resistance to antibiotics, especially dual resistance to clarithromycin and metronidazole. However, microbiological culture data on drug-resistant H. pylori is lacking. This study evaluated the antimicrobial efficacy of candidate antibiotics against resistant H. pylori strains. Methods. After retrospectively reviewing the data from the Helicobacter Registry in Gil Medical Center (GMC) and Asan Medical Center (AMC), along with 4 reference strains, we selected the 31 single- or multidrug-resistant strains. The susceptibility of the H. pylori strains to seven antibiotics (clarithromycin, metronidazole, levofloxacin, amoxicillin, tetracycline, rifabutin, and furazolidone) and minimum inhibitory concentration were tested using the broth microdilution technique. Results. Among 31 antibiotic resistance strains for H. pylori, there were no strains resistant to rifabutin or furazolidone, which had MICs of <0.008 and 0.5 μg/mL, respectively. Only one tetracycline-resistant strain was found (MIC < 2 μg/mL). Amoxicillin and levofloxacin were relatively less effective against the H. pylori strains compared to rifabutin or furazolidone (resistance rates 22.6%, 1.9%, respectively). Tetracycline showed the relatively low resistance rates (3.2%) for H. pylori strains. Conclusions. Therefore, along with tetracycline which has already been used as a component for second-line eradication regimen for Helicobacter, rifabutin and furazolidone, alone or in combination, could be used to eradicate antibiotic-resistant H. pylori strains where drug-resistant Helicobacter spp. are increasing. |
| format | Article |
| id | doaj-art-0d2d008b62b04679840e37ead2b5f820 |
| institution | Kabale University |
| issn | 1712-9532 1918-1493 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Infectious Diseases and Medical Microbiology |
| spelling | doaj-art-0d2d008b62b04679840e37ead2b5f8202025-02-03T01:06:13ZengWileyCanadian Journal of Infectious Diseases and Medical Microbiology1712-95321918-14932019-01-01201910.1155/2019/93518019351801Rifabutin and Furazolidone Could Be the Candidates of the Rescue Regimen for Antibiotic-Resistant H. pylori in KoreaYoun I Choi0Sang-Ho Jeong1Jun-Won Chung2Dong Kyun Park3Kyoung Oh Kim4Kwang An Kwon5Yoon Jae Kim6Seol So7Jeong Hoon Lee8Jin-Young Jeong9Sun-Mi Lee10Department of Gastroenterology, Gil Medical Center, Gachon University, Incheon, Republic of KoreaDepartment of Gastroenterology, Gil Medical Center, Gachon University, Incheon, Republic of KoreaDepartment of Gastroenterology, Gil Medical Center, Gachon University, Incheon, Republic of KoreaDepartment of Gastroenterology, Gil Medical Center, Gachon University, Incheon, Republic of KoreaDepartment of Gastroenterology, Gil Medical Center, Gachon University, Incheon, Republic of KoreaDepartment of Gastroenterology, Gil Medical Center, Gachon University, Incheon, Republic of KoreaDepartment of Gastroenterology, Gil Medical Center, Gachon University, Incheon, Republic of KoreaDepartment of Gastroenterology, Asan Medical Center, Ulsan University, Seoul, Republic of KoreaDepartment of Gastroenterology, Asan Medical Center, Ulsan University, Seoul, Republic of KoreaAsan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, Republic of KoreaAsan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, Republic of KoreaBackground/Aim. In Korea, the rate of Helicobacter pylori (H. pylori) eradication has declined steadily as a result of increasing resistance to antibiotics, especially dual resistance to clarithromycin and metronidazole. However, microbiological culture data on drug-resistant H. pylori is lacking. This study evaluated the antimicrobial efficacy of candidate antibiotics against resistant H. pylori strains. Methods. After retrospectively reviewing the data from the Helicobacter Registry in Gil Medical Center (GMC) and Asan Medical Center (AMC), along with 4 reference strains, we selected the 31 single- or multidrug-resistant strains. The susceptibility of the H. pylori strains to seven antibiotics (clarithromycin, metronidazole, levofloxacin, amoxicillin, tetracycline, rifabutin, and furazolidone) and minimum inhibitory concentration were tested using the broth microdilution technique. Results. Among 31 antibiotic resistance strains for H. pylori, there were no strains resistant to rifabutin or furazolidone, which had MICs of <0.008 and 0.5 μg/mL, respectively. Only one tetracycline-resistant strain was found (MIC < 2 μg/mL). Amoxicillin and levofloxacin were relatively less effective against the H. pylori strains compared to rifabutin or furazolidone (resistance rates 22.6%, 1.9%, respectively). Tetracycline showed the relatively low resistance rates (3.2%) for H. pylori strains. Conclusions. Therefore, along with tetracycline which has already been used as a component for second-line eradication regimen for Helicobacter, rifabutin and furazolidone, alone or in combination, could be used to eradicate antibiotic-resistant H. pylori strains where drug-resistant Helicobacter spp. are increasing.http://dx.doi.org/10.1155/2019/9351801 |
| spellingShingle | Youn I Choi Sang-Ho Jeong Jun-Won Chung Dong Kyun Park Kyoung Oh Kim Kwang An Kwon Yoon Jae Kim Seol So Jeong Hoon Lee Jin-Young Jeong Sun-Mi Lee Rifabutin and Furazolidone Could Be the Candidates of the Rescue Regimen for Antibiotic-Resistant H. pylori in Korea Canadian Journal of Infectious Diseases and Medical Microbiology |
| title | Rifabutin and Furazolidone Could Be the Candidates of the Rescue Regimen for Antibiotic-Resistant H. pylori in Korea |
| title_full | Rifabutin and Furazolidone Could Be the Candidates of the Rescue Regimen for Antibiotic-Resistant H. pylori in Korea |
| title_fullStr | Rifabutin and Furazolidone Could Be the Candidates of the Rescue Regimen for Antibiotic-Resistant H. pylori in Korea |
| title_full_unstemmed | Rifabutin and Furazolidone Could Be the Candidates of the Rescue Regimen for Antibiotic-Resistant H. pylori in Korea |
| title_short | Rifabutin and Furazolidone Could Be the Candidates of the Rescue Regimen for Antibiotic-Resistant H. pylori in Korea |
| title_sort | rifabutin and furazolidone could be the candidates of the rescue regimen for antibiotic resistant h pylori in korea |
| url | http://dx.doi.org/10.1155/2019/9351801 |
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