(-)-Fenchone Ameliorates TNBS-Induced Colitis in Rats via Antioxidant, Immunomodulatory, and Cytoprotective Mechanisms
Background: (-)-Fenchone is a bicyclic monoterpene present in the plant species <i>Foeniculum vulgare</i> Mill, <i>Thuja occidentalis</i> L. (tuja), and <i>Lavandula stoechas</i> (lavender). These plants have therapeutic value in the treatment of intestinal disord...
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MDPI AG
2024-12-01
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| author | Maria Elaine Cristina Araruna Edvaldo Balbino Alves Júnior Catarina Alves de Lima Serafim Matheus Marley Bezerra Pessoa Michelle Liz de Souza Pessôa Vitória Pereira Alves Marianna Vieira Sobral Marcelo Sobral da Silva Adriano Francisco Alves Maria Carolina de Paiva Sousa Aurigena Antunes Araújo Leônia Maria Batista |
| author_facet | Maria Elaine Cristina Araruna Edvaldo Balbino Alves Júnior Catarina Alves de Lima Serafim Matheus Marley Bezerra Pessoa Michelle Liz de Souza Pessôa Vitória Pereira Alves Marianna Vieira Sobral Marcelo Sobral da Silva Adriano Francisco Alves Maria Carolina de Paiva Sousa Aurigena Antunes Araújo Leônia Maria Batista |
| author_sort | Maria Elaine Cristina Araruna |
| collection | DOAJ |
| description | Background: (-)-Fenchone is a bicyclic monoterpene present in the plant species <i>Foeniculum vulgare</i> Mill, <i>Thuja occidentalis</i> L. (tuja), and <i>Lavandula stoechas</i> (lavender). These plants have therapeutic value in the treatment of intestinal disorders. Aim: To evaluate intestinal anti-inflammatory activity in an acute and chronic trinitrobenzene sulphonic acid (TNBS)-induced colitis model in rats. Methods: Intestinal anti-inflammatory effects were assessed using the acute and chronic TNBS-induced colitis model in rats. The mechanisms were evaluated from colonic tissue fragments of the acute and chronic models. Results: Oral administration of the (-)-fenchone (37.5–300 mg/kg) acute phase or (150 mg/kg) (<i>p</i> < 0.001) chronic phase reduced the macroscopic lesion score, ulcerative area, intestinal weight/length ratio, and diarrheal index in TNBS-treated animals. At a dose of 150 mg/kg, the acute and chronic phase decreased malondialdehyde (MDA) and myeloperoxidase (MPO) (<i>p</i> < 0.001), restored glutathione (GSH) levels and superoxide dismutase (SOD) (<i>p</i> < 0.001), decreased immunomarking for factor nuclear kappa B (NF-κB) and levels of interleukin (IL)-1 and tumor necrosis factor α (TNF-α), and maintained IL-10 and TGF-β basal levels. Furthermore, increased immunostaining for zonula occludens 1 (ZO-1) was observed. Conclusions: (-)-fenchone has intestinal anti-inflammatory activity related to cytoprotection of the intestinal barrier, as well as antioxidant and immunomodulatory effects. |
| format | Article |
| id | doaj-art-0d18d55824a7477e842561cdbd7c8329 |
| institution | Kabale University |
| issn | 1424-8247 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
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| spelling | doaj-art-0d18d55824a7477e842561cdbd7c83292025-01-24T13:45:01ZengMDPI AGPharmaceuticals1424-82472024-12-011811810.3390/ph18010018(-)-Fenchone Ameliorates TNBS-Induced Colitis in Rats via Antioxidant, Immunomodulatory, and Cytoprotective MechanismsMaria Elaine Cristina Araruna0Edvaldo Balbino Alves Júnior1Catarina Alves de Lima Serafim2Matheus Marley Bezerra Pessoa3Michelle Liz de Souza Pessôa4Vitória Pereira Alves5Marianna Vieira Sobral6Marcelo Sobral da Silva7Adriano Francisco Alves8Maria Carolina de Paiva Sousa9Aurigena Antunes Araújo10Leônia Maria Batista11Postgraduate Program in Natural and Synthetic Bioactive Products, Health Sciences Center, Federal University of Paraíba (UFPB), João Pessoa CEP 58051-970, PB, BrazilPostgraduate Program in Natural and Synthetic Bioactive Products, Health Sciences Center, Federal University of Paraíba (UFPB), João Pessoa CEP 58051-970, PB, BrazilPostgraduate Program in Natural and Synthetic Bioactive Products, Health Sciences Center, Federal University of Paraíba (UFPB), João Pessoa CEP 58051-970, PB, BrazilPostgraduate Program in Natural and Synthetic Bioactive Products, Health Sciences Center, Federal University of Paraíba (UFPB), João Pessoa CEP 58051-970, PB, BrazilPostgraduate Program in Natural and Synthetic Bioactive Products, Health Sciences Center, Federal University of Paraíba (UFPB), João Pessoa CEP 58051-970, PB, BrazilPostgraduate Program in Natural and Synthetic Bioactive Products, Health Sciences Center, Federal University of Paraíba (UFPB), João Pessoa CEP 58051-970, PB, BrazilPostgraduate Program in Natural and Synthetic Bioactive Products, Health Sciences Center, Federal University of Paraíba (UFPB), João Pessoa CEP 58051-970, PB, BrazilPostgraduate Program in Natural and Synthetic Bioactive Products, Health Sciences Center, Federal University of Paraíba (UFPB), João Pessoa CEP 58051-970, PB, BrazilPostgraduate Program in Natural and Synthetic Bioactive Products, Health Sciences Center, Federal University of Paraíba (UFPB), João Pessoa CEP 58051-970, PB, BrazilDepartment of Physiology and Pathology, Health Sciences Center, Federal University of Paraíba (UFPB), João Pessoa CEP 58051-970, PB, BrazilDepartment of Morphology, Histology and Basic Pathology, Biosciences Center, Federal University of Rio Grande do Norte (UFRN), Natal CEP 59078-970, RN, BrazilPostgraduate Program in Natural and Synthetic Bioactive Products, Health Sciences Center, Federal University of Paraíba (UFPB), João Pessoa CEP 58051-970, PB, BrazilBackground: (-)-Fenchone is a bicyclic monoterpene present in the plant species <i>Foeniculum vulgare</i> Mill, <i>Thuja occidentalis</i> L. (tuja), and <i>Lavandula stoechas</i> (lavender). These plants have therapeutic value in the treatment of intestinal disorders. Aim: To evaluate intestinal anti-inflammatory activity in an acute and chronic trinitrobenzene sulphonic acid (TNBS)-induced colitis model in rats. Methods: Intestinal anti-inflammatory effects were assessed using the acute and chronic TNBS-induced colitis model in rats. The mechanisms were evaluated from colonic tissue fragments of the acute and chronic models. Results: Oral administration of the (-)-fenchone (37.5–300 mg/kg) acute phase or (150 mg/kg) (<i>p</i> < 0.001) chronic phase reduced the macroscopic lesion score, ulcerative area, intestinal weight/length ratio, and diarrheal index in TNBS-treated animals. At a dose of 150 mg/kg, the acute and chronic phase decreased malondialdehyde (MDA) and myeloperoxidase (MPO) (<i>p</i> < 0.001), restored glutathione (GSH) levels and superoxide dismutase (SOD) (<i>p</i> < 0.001), decreased immunomarking for factor nuclear kappa B (NF-κB) and levels of interleukin (IL)-1 and tumor necrosis factor α (TNF-α), and maintained IL-10 and TGF-β basal levels. Furthermore, increased immunostaining for zonula occludens 1 (ZO-1) was observed. Conclusions: (-)-fenchone has intestinal anti-inflammatory activity related to cytoprotection of the intestinal barrier, as well as antioxidant and immunomodulatory effects.https://www.mdpi.com/1424-8247/18/1/18(-)-fenchoneulcerative colitisantioxidantimmunomodulatorycytoprotection |
| spellingShingle | Maria Elaine Cristina Araruna Edvaldo Balbino Alves Júnior Catarina Alves de Lima Serafim Matheus Marley Bezerra Pessoa Michelle Liz de Souza Pessôa Vitória Pereira Alves Marianna Vieira Sobral Marcelo Sobral da Silva Adriano Francisco Alves Maria Carolina de Paiva Sousa Aurigena Antunes Araújo Leônia Maria Batista (-)-Fenchone Ameliorates TNBS-Induced Colitis in Rats via Antioxidant, Immunomodulatory, and Cytoprotective Mechanisms Pharmaceuticals (-)-fenchone ulcerative colitis antioxidant immunomodulatory cytoprotection |
| title | (-)-Fenchone Ameliorates TNBS-Induced Colitis in Rats via Antioxidant, Immunomodulatory, and Cytoprotective Mechanisms |
| title_full | (-)-Fenchone Ameliorates TNBS-Induced Colitis in Rats via Antioxidant, Immunomodulatory, and Cytoprotective Mechanisms |
| title_fullStr | (-)-Fenchone Ameliorates TNBS-Induced Colitis in Rats via Antioxidant, Immunomodulatory, and Cytoprotective Mechanisms |
| title_full_unstemmed | (-)-Fenchone Ameliorates TNBS-Induced Colitis in Rats via Antioxidant, Immunomodulatory, and Cytoprotective Mechanisms |
| title_short | (-)-Fenchone Ameliorates TNBS-Induced Colitis in Rats via Antioxidant, Immunomodulatory, and Cytoprotective Mechanisms |
| title_sort | fenchone ameliorates tnbs induced colitis in rats via antioxidant immunomodulatory and cytoprotective mechanisms |
| topic | (-)-fenchone ulcerative colitis antioxidant immunomodulatory cytoprotection |
| url | https://www.mdpi.com/1424-8247/18/1/18 |
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