Ischaemia-reperfusion time differences in ST-elevation myocardial infarction in very young patients: a cohort study
Introduction ST-elevation myocardial infarction (STEMI) is one of the most prevalent presentations in young patients. It is essential to emphasise that each minute of delay in providing medical care is negatively correlated to the patient’s prognosis. The present study was carried out to evaluate th...
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BMJ Publishing Group
2025-01-01
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| Series: | Open Heart |
| Online Access: | https://openheart.bmj.com/content/12/1/e002957.full |
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| author | Pablo Juan-Salvadores Luis Mariano De La Torre Fonseca Beatriz Calderon-Cruz Cesar Veiga Samuel Pintos-Rodríguez Saleta Fernandez Barbeira Victor Alfonso Jimenez Diaz Andres Iñiguez Romo |
| author_facet | Pablo Juan-Salvadores Luis Mariano De La Torre Fonseca Beatriz Calderon-Cruz Cesar Veiga Samuel Pintos-Rodríguez Saleta Fernandez Barbeira Victor Alfonso Jimenez Diaz Andres Iñiguez Romo |
| author_sort | Pablo Juan-Salvadores |
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| description | Introduction ST-elevation myocardial infarction (STEMI) is one of the most prevalent presentations in young patients. It is essential to emphasise that each minute of delay in providing medical care is negatively correlated to the patient’s prognosis. The present study was carried out to evaluate the ischaemia-reperfusion times in patients ≤40 years of age versus individuals >40 years of age and their association with mortality and major adverse cardiac event (MACE) over the long term.Methods A retrospective, multicentre cohort study was carried out in 6799 patients diagnosed with STEMI. Two groups were established: patients diagnosed with STEMI and aged >40 years, and patients diagnosed with STEMI and aged ≤40 years.Results The patients in the young group had a significantly sooner electrocardiographic diagnosis than the patients >40 years of age. A delay was observed in females, with a relative risk (RR) of 1.21 (95% CI 1.13 to 1.30) (p<0.001). Presenting dyspnoea (RR 1.76, 95% CI 1.5 to 2.06) (p<0.001) or going to a hospital without haemodynamics (RR 1.55, 95% CI 1.45 to 1.67) (p<0.001) was related to increased delay. The occurrence of MACE in the first year of follow-up was related to different risk factors, along with a delay in healthcare (HR 1.25, 95% CI 1.10 to 1.54) (p<0.042).Conclusion This study shows that young patients with STEMI tend to receive a sooner diagnosis than older individuals. Delays in healthcare represent one of the main factors related to the occurrence of MACE and non-event-free survival. |
| format | Article |
| id | doaj-art-0cf84410ba2f4a099804d8a8b373f340 |
| institution | Kabale University |
| issn | 2053-3624 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMJ Publishing Group |
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| series | Open Heart |
| spelling | doaj-art-0cf84410ba2f4a099804d8a8b373f3402025-01-29T05:50:09ZengBMJ Publishing GroupOpen Heart2053-36242025-01-0112110.1136/openhrt-2024-002957Ischaemia-reperfusion time differences in ST-elevation myocardial infarction in very young patients: a cohort studyPablo Juan-Salvadores0Luis Mariano De La Torre Fonseca1Beatriz Calderon-Cruz2Cesar Veiga3Samuel Pintos-Rodríguez4Saleta Fernandez Barbeira5Victor Alfonso Jimenez Diaz6Andres Iñiguez Romo7Cardiology, Hospital Alvaro Cunqueiro, Vigo, SpainIntensive Care Unit, Hospital Comandante Manuel Fajardo, La Habana, CubaMethodolgy Unit, Galicia Sur Health Research Institute (IIS Galicia Sur), Vigo, SpainCardiology, Hospital Alvaro Cunqueiro, Vigo, SpainCardiology, Hospital Alvaro Cunqueiro, Vigo, SpainCardiology, Hospital Alvaro Cunqueiro, Vigo, SpainCardiology, Hospital Alvaro Cunqueiro, Vigo, SpainCardiology, Hospital Alvaro Cunqueiro, Vigo, SpainIntroduction ST-elevation myocardial infarction (STEMI) is one of the most prevalent presentations in young patients. It is essential to emphasise that each minute of delay in providing medical care is negatively correlated to the patient’s prognosis. The present study was carried out to evaluate the ischaemia-reperfusion times in patients ≤40 years of age versus individuals >40 years of age and their association with mortality and major adverse cardiac event (MACE) over the long term.Methods A retrospective, multicentre cohort study was carried out in 6799 patients diagnosed with STEMI. Two groups were established: patients diagnosed with STEMI and aged >40 years, and patients diagnosed with STEMI and aged ≤40 years.Results The patients in the young group had a significantly sooner electrocardiographic diagnosis than the patients >40 years of age. A delay was observed in females, with a relative risk (RR) of 1.21 (95% CI 1.13 to 1.30) (p<0.001). Presenting dyspnoea (RR 1.76, 95% CI 1.5 to 2.06) (p<0.001) or going to a hospital without haemodynamics (RR 1.55, 95% CI 1.45 to 1.67) (p<0.001) was related to increased delay. The occurrence of MACE in the first year of follow-up was related to different risk factors, along with a delay in healthcare (HR 1.25, 95% CI 1.10 to 1.54) (p<0.042).Conclusion This study shows that young patients with STEMI tend to receive a sooner diagnosis than older individuals. Delays in healthcare represent one of the main factors related to the occurrence of MACE and non-event-free survival.https://openheart.bmj.com/content/12/1/e002957.full |
| spellingShingle | Pablo Juan-Salvadores Luis Mariano De La Torre Fonseca Beatriz Calderon-Cruz Cesar Veiga Samuel Pintos-Rodríguez Saleta Fernandez Barbeira Victor Alfonso Jimenez Diaz Andres Iñiguez Romo Ischaemia-reperfusion time differences in ST-elevation myocardial infarction in very young patients: a cohort study Open Heart |
| title | Ischaemia-reperfusion time differences in ST-elevation myocardial infarction in very young patients: a cohort study |
| title_full | Ischaemia-reperfusion time differences in ST-elevation myocardial infarction in very young patients: a cohort study |
| title_fullStr | Ischaemia-reperfusion time differences in ST-elevation myocardial infarction in very young patients: a cohort study |
| title_full_unstemmed | Ischaemia-reperfusion time differences in ST-elevation myocardial infarction in very young patients: a cohort study |
| title_short | Ischaemia-reperfusion time differences in ST-elevation myocardial infarction in very young patients: a cohort study |
| title_sort | ischaemia reperfusion time differences in st elevation myocardial infarction in very young patients a cohort study |
| url | https://openheart.bmj.com/content/12/1/e002957.full |
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