Spatial transcriptomic and morpho-functional information derived from single mouse FFPE slides allows in-depth fingerprinting of lung fibrosis

Spatial transcriptomic and morpho-functional information derived from single mouse FFPE slides allows in-depth fingerprinting of lung fibrosis

Abstract Background Transcriptome profiling by RNA sequencing (RNAseq) can provide insightful information on the molecular processes underlying disease development and progression. Although fresh tissue represents the preferred source material for RNAseq, here, we investigated the feasibility of app...

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Main Authors: Erica Ferrini, Costanza Bonfini, Giovanna Marchese, Martina Buccardi, Matteo Zoboli, Primetta Faccioli, Nicola Sverzellati, Gino Villetti, Simone Ottonello, Maria Ravo, Franco F. Stellari
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Respiratory Research
Subjects:
RNAseq
FFPE lung slide
Micro-CT imaging
Histology
Pulmonary fibrosis mouse model
Bleomycin
Online Access:https://doi.org/10.1186/s12931-025-03300-y
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https://doi.org/10.1186/s12931-025-03300-y

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