Thyroid-Specific Genes Expression Uncovered Age-Related Differences in Pediatric Thyroid Carcinomas
Despite a more advanced stage of disease at presentation, a better response to radioiodine (RAI) therapy and a reduced overall mortality have been reported in pediatric differentiated thyroid cancer (DTC) in comparison to adult DTC. Few studies suggested that the better response to RAI therapy in pe...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2016/1956740 |
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| author | Maria Isabel Cunha Vieira Cordioli Lais Moraes Maria Teresa de Seixas Alves Rosana Delcelo Osmar Monte Carlos Alberto Longui Adriano Namo Cury Janete Maria Cerutti |
| author_facet | Maria Isabel Cunha Vieira Cordioli Lais Moraes Maria Teresa de Seixas Alves Rosana Delcelo Osmar Monte Carlos Alberto Longui Adriano Namo Cury Janete Maria Cerutti |
| author_sort | Maria Isabel Cunha Vieira Cordioli |
| collection | DOAJ |
| description | Despite a more advanced stage of disease at presentation, a better response to radioiodine (RAI) therapy and a reduced overall mortality have been reported in pediatric differentiated thyroid cancer (DTC) in comparison to adult DTC. Few studies suggested that the better response to RAI therapy in pediatric patients might be associated with an increased expression of NIS. However, a marked heterogeneity within the pediatric group has been recognized. Children (<10 years old) usually present a more aggressive disease than adolescents (≥10–18 years old). By analyzing the expression of thyroid-specific genes in 38 sporadic pediatric tumors, we show that the expression of NIS, PDS, and TSHR was lower in children than adolescents (P<0.05). A linear regression confirmed the association between NIS expression and age. Most significantly, NIS was expressed at similar levels in DTC from children and adults, whereas PDS and TSHR expression was even lower in DTC from children, compared to adolescents and adults. Our data suggest that biological behaviors of DTC in adolescents might differ from those in children and adults. Therefore, the premise that the expression of thyroid-specific genes is higher in tumors from pediatric patients than in adults is not entirely true and might be too oversimplified. |
| format | Article |
| id | doaj-art-0c70d120e8c3420794c38cda4ec819fe |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-0c70d120e8c3420794c38cda4ec819fe2025-02-03T06:01:48ZengWileyInternational Journal of Endocrinology1687-83371687-83452016-01-01201610.1155/2016/19567401956740Thyroid-Specific Genes Expression Uncovered Age-Related Differences in Pediatric Thyroid CarcinomasMaria Isabel Cunha Vieira Cordioli0Lais Moraes1Maria Teresa de Seixas Alves2Rosana Delcelo3Osmar Monte4Carlos Alberto Longui5Adriano Namo Cury6Janete Maria Cerutti7Genetic Bases of Thyroid Tumors Laboratory, Division of Genetics, Department of Morphology and Genetics and Division of Endocrinology, Department of Medicine, Universidade Federal de São Paulo, Pedro de Toledo 669, 11 Andar, 04039-032 São Paulo, SP, BrazilGenetic Bases of Thyroid Tumors Laboratory, Division of Genetics, Department of Morphology and Genetics and Division of Endocrinology, Department of Medicine, Universidade Federal de São Paulo, Pedro de Toledo 669, 11 Andar, 04039-032 São Paulo, SP, BrazilPediatric Section, Department of Pathology, Universidade Federal de São Paulo, Rua Botucatu 740, 04023-900 São Paulo, SP, BrazilThyroid Section, Department of Pathology, Universidade Federal de São Paulo, Rua Botucatu 740, 04023-900 São Paulo, SP, BrazilMolecular Medicine Laboratory, Irmandade da Santa Casa de Misericórdia de São Paulo, Rua Dr. Cesário Mota Jr. 112, 01221-020 São Paulo, SP, BrazilMolecular Medicine Laboratory, Irmandade da Santa Casa de Misericórdia de São Paulo, Rua Dr. Cesário Mota Jr. 112, 01221-020 São Paulo, SP, BrazilDivision of Endocrinology, Irmandade da Santa Casa de Misericórdia de São Paulo, Rua Dr. Cesário Mota Jr. 112, 01221-020 São Paulo, SP, BrazilGenetic Bases of Thyroid Tumors Laboratory, Division of Genetics, Department of Morphology and Genetics and Division of Endocrinology, Department of Medicine, Universidade Federal de São Paulo, Pedro de Toledo 669, 11 Andar, 04039-032 São Paulo, SP, BrazilDespite a more advanced stage of disease at presentation, a better response to radioiodine (RAI) therapy and a reduced overall mortality have been reported in pediatric differentiated thyroid cancer (DTC) in comparison to adult DTC. Few studies suggested that the better response to RAI therapy in pediatric patients might be associated with an increased expression of NIS. However, a marked heterogeneity within the pediatric group has been recognized. Children (<10 years old) usually present a more aggressive disease than adolescents (≥10–18 years old). By analyzing the expression of thyroid-specific genes in 38 sporadic pediatric tumors, we show that the expression of NIS, PDS, and TSHR was lower in children than adolescents (P<0.05). A linear regression confirmed the association between NIS expression and age. Most significantly, NIS was expressed at similar levels in DTC from children and adults, whereas PDS and TSHR expression was even lower in DTC from children, compared to adolescents and adults. Our data suggest that biological behaviors of DTC in adolescents might differ from those in children and adults. Therefore, the premise that the expression of thyroid-specific genes is higher in tumors from pediatric patients than in adults is not entirely true and might be too oversimplified.http://dx.doi.org/10.1155/2016/1956740 |
| spellingShingle | Maria Isabel Cunha Vieira Cordioli Lais Moraes Maria Teresa de Seixas Alves Rosana Delcelo Osmar Monte Carlos Alberto Longui Adriano Namo Cury Janete Maria Cerutti Thyroid-Specific Genes Expression Uncovered Age-Related Differences in Pediatric Thyroid Carcinomas International Journal of Endocrinology |
| title | Thyroid-Specific Genes Expression Uncovered Age-Related Differences in Pediatric Thyroid Carcinomas |
| title_full | Thyroid-Specific Genes Expression Uncovered Age-Related Differences in Pediatric Thyroid Carcinomas |
| title_fullStr | Thyroid-Specific Genes Expression Uncovered Age-Related Differences in Pediatric Thyroid Carcinomas |
| title_full_unstemmed | Thyroid-Specific Genes Expression Uncovered Age-Related Differences in Pediatric Thyroid Carcinomas |
| title_short | Thyroid-Specific Genes Expression Uncovered Age-Related Differences in Pediatric Thyroid Carcinomas |
| title_sort | thyroid specific genes expression uncovered age related differences in pediatric thyroid carcinomas |
| url | http://dx.doi.org/10.1155/2016/1956740 |
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