Complex IIa formation and ABC transporters determine sensitivity of OSCC to Smac mimetics

Complex IIa formation and ABC transporters determine sensitivity of OSCC to Smac mimetics

Abstract Small molecule inhibitors of apoptosis proteins (IAPs) antagonists, known as Smac mimetics (SMs), activate non-canonical NF-κB and sensitize cancer cells to TNF-induced cell death. SMs are currently in phase III clinical trials for head and neck squamous cell carcinoma (HNSCC) after promisi...

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Main Authors: Yuhan Wang, Zijian Liu, Qian Si, Wanqiu Lu, Yuxian Song, Wanyong Jin, Xihu Yang, Zihui Li, Xinyang Hu, Liang Ding, Yue Jing, Pei Weng, Qiuya Yu, Lorraine A. O’Reilly, John Silke, Xiaoxin Zhang, Qingang Hu, Yanhong Ni
Format: Article
Language:English
Published: Nature Publishing Group 2024-11-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-024-07253-w
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https://doi.org/10.1038/s41419-024-07253-w

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