Chromosomal Instability Is Associated with cGAS–STING Activation in EGFR-TKI Refractory Non-Small-Cell Lung Cancer

Chromosomal Instability Is Associated with cGAS–STING Activation in EGFR-TKI Refractory Non-Small-Cell Lung Cancer

Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) are standard therapies for <i>EGFR</i>-mutated non-small-cell lung cancer (NSCLC); however, their efficacy is inconsistent. Secondary mutations in the <i>EGFR</i> or other genes that lead to resistance ha...

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Main Authors: Kimio Yonesaka, Takashi Kurosaki, Junko Tanizaki, Hisato Kawakami, Kaoru Tanaka, Osamu Maenishi, Shiki Takamura, Kazuko Sakai, Yasutaka Chiba, Takeshi Teramura, Hiroki Goto, Eri Otsuka, Hiroaki Okida, Masanori Funabashi, Yuuri Hashimoto, Kenji Hirotani, Yasuki Kamai, Takashi Kagari, Kazuto Nishio, Kazuhiro Kakimi, Hidetoshi Hayashi
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Cells
Subjects:
EGFR-mutated non-small-cell lung cancer
epidermal growth factor receptor tyrosine kinase inhibitors
chromosomal instability
Online Access:https://www.mdpi.com/2073-4409/14/6/447
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