Enforcement of stem-cell dormancy by nucleophosmin mutation is a critical determinant of unrestricted self-renewal during myeloid leukemogenesis

Enforcement of stem-cell dormancy by nucleophosmin mutation is a critical determinant of unrestricted self-renewal during myeloid leukemogenesis

Mutations in the NPM1 gene (NPMc+) and in the FLT3 gene (FLT3-ITD) represent the most frequent co-occurring mutations in Acute Myeloid Leukemia (AML), yet the cellular and molecular mechanisms of their cooperation remain largely unexplored. Using mouse models that faithfully recapitulate human AML,...

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Main Authors: Maria Elena Boggio Merlo, Maria Mallardo, Lucilla Luzi, Giulia De Conti, Chiara Caprioli, Roman Hillje, Mario Faretta, Cecilia Restelli, Andrea Polazzi, Valentina Tabanelli, Angelica Calleri, Stefano Pileri, Pier Giuseppe Pelicci, Emanuela Colombo
Format: Article
Language:English
Published: Ferrata Storti Foundation 2025-03-01
Series:Haematologica
Online Access:https://haematologica.org/article/view/11973
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