Study on the correlation between serum IgG4/IgG levels and the development of Graves’ ophthalmopathy
Abstract Graves’ ophthalmopathy (GO) with elevated IgG4 levels has different characteristics from patients with GO who do not have elevated IgG4 levels, but the study findings are contradictory. The goal of this study was first to investigate the relationship between IgG4/IgG and IgG4 levels and the...
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Nature Portfolio
2025-01-01
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| Online Access: | https://doi.org/10.1038/s41598-025-87126-0 |
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| author | Yuanyuan Deng Zejin Hao Shanshan Li Junping Zhang Jie Zhang Huaxia Gan Wei Cai Yang Liu Jixiong Xu |
| author_facet | Yuanyuan Deng Zejin Hao Shanshan Li Junping Zhang Jie Zhang Huaxia Gan Wei Cai Yang Liu Jixiong Xu |
| author_sort | Yuanyuan Deng |
| collection | DOAJ |
| description | Abstract Graves’ ophthalmopathy (GO) with elevated IgG4 levels has different characteristics from patients with GO who do not have elevated IgG4 levels, but the study findings are contradictory. The goal of this study was first to investigate the relationship between IgG4/IgG and IgG4 levels and the occurrence of GO and then to investigate the clinical and laboratory characteristics of patients with GO who had elevated IgG4 levels. This study control group consisted of 57 Graves’ disease(GD)patients with no complicated ocular disease and a median followup of 54.41 months, while the experimental group included 171 GO patients. The clinical and laboratory characteristics of the GD and GO groups were compared. Using an IgG4/IgG cut-off value of 8%, the GO patients were divided into two groups: high IgG4/IgG and low IgG4/IgG, and the differences in clinical and laboratory characteristics between these two groups, as well as between the GO patients before and after 3 months of treatment, were analyzed. The study results show that serum IgG4/IgG levels were independently correlated with the occurrence of GO, but not significantly correlated with GO activity. Patients with high IgG4/IgG levels of GO exhibit distinct characteristics, which may be associated with an unstable balance of lymphocyte subsets. |
| format | Article |
| id | doaj-art-0c26b5177dfa4d3f9dbcb8f5e5f2d593 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-0c26b5177dfa4d3f9dbcb8f5e5f2d5932025-01-26T12:29:44ZengNature PortfolioScientific Reports2045-23222025-01-011511810.1038/s41598-025-87126-0Study on the correlation between serum IgG4/IgG levels and the development of Graves’ ophthalmopathyYuanyuan Deng0Zejin Hao1Shanshan Li2Junping Zhang3Jie Zhang4Huaxia Gan5Wei Cai6Yang Liu7Jixiong Xu8Department of Endocrinology and Metabolism, The First Affiliated Hospital, Jiangxi Medical College, Nanchang UniversityDepartment of Endocrinology and Metabolism, The First Affiliated Hospital, Jiangxi Medical College, Nanchang UniversityDepartment of Endocrinology and Metabolism, The First Affiliated Hospital, Jiangxi Medical College, Nanchang UniversityDepartment of Endocrinology and Metabolism, The First Affiliated Hospital, Jiangxi Medical College, Nanchang UniversityDepartment of Endocrinology and Metabolism, The First Affiliated Hospital, Jiangxi Medical College, Nanchang UniversityDepartment of Endocrinology and Metabolism, The First Affiliated Hospital, Jiangxi Medical College, Nanchang UniversityDepartment of Medical Genetics and Cell biology, Medical College of Nanchang UniversityDepartment of Clinical Laboratory, The First Affiliated Hospital, Jiangxi Medical College, Nanchang UniversityDepartment of Endocrinology and Metabolism, The First Affiliated Hospital, Jiangxi Medical College, Nanchang UniversityAbstract Graves’ ophthalmopathy (GO) with elevated IgG4 levels has different characteristics from patients with GO who do not have elevated IgG4 levels, but the study findings are contradictory. The goal of this study was first to investigate the relationship between IgG4/IgG and IgG4 levels and the occurrence of GO and then to investigate the clinical and laboratory characteristics of patients with GO who had elevated IgG4 levels. This study control group consisted of 57 Graves’ disease(GD)patients with no complicated ocular disease and a median followup of 54.41 months, while the experimental group included 171 GO patients. The clinical and laboratory characteristics of the GD and GO groups were compared. Using an IgG4/IgG cut-off value of 8%, the GO patients were divided into two groups: high IgG4/IgG and low IgG4/IgG, and the differences in clinical and laboratory characteristics between these two groups, as well as between the GO patients before and after 3 months of treatment, were analyzed. The study results show that serum IgG4/IgG levels were independently correlated with the occurrence of GO, but not significantly correlated with GO activity. Patients with high IgG4/IgG levels of GO exhibit distinct characteristics, which may be associated with an unstable balance of lymphocyte subsets.https://doi.org/10.1038/s41598-025-87126-0Graves’ ophthalmopathyGraves’ diseaseIgG4/IgGClinical features |
| spellingShingle | Yuanyuan Deng Zejin Hao Shanshan Li Junping Zhang Jie Zhang Huaxia Gan Wei Cai Yang Liu Jixiong Xu Study on the correlation between serum IgG4/IgG levels and the development of Graves’ ophthalmopathy Scientific Reports Graves’ ophthalmopathy Graves’ disease IgG4/IgG Clinical features |
| title | Study on the correlation between serum IgG4/IgG levels and the development of Graves’ ophthalmopathy |
| title_full | Study on the correlation between serum IgG4/IgG levels and the development of Graves’ ophthalmopathy |
| title_fullStr | Study on the correlation between serum IgG4/IgG levels and the development of Graves’ ophthalmopathy |
| title_full_unstemmed | Study on the correlation between serum IgG4/IgG levels and the development of Graves’ ophthalmopathy |
| title_short | Study on the correlation between serum IgG4/IgG levels and the development of Graves’ ophthalmopathy |
| title_sort | study on the correlation between serum igg4 igg levels and the development of graves ophthalmopathy |
| topic | Graves’ ophthalmopathy Graves’ disease IgG4/IgG Clinical features |
| url | https://doi.org/10.1038/s41598-025-87126-0 |
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