Rational design, and synthesis of imidazole ring incorporated Pyridine-1,2,4-oxadiazole derivatives: In-vitro anticancer evaluation and in-silico molecular docking simulations

Rational design, and synthesis of imidazole ring incorporated Pyridine-1,2,4-oxadiazole derivatives: In-vitro anticancer evaluation and in-silico molecular docking simulations

We have design and developed a new library of imidazole ring incorporated pyridine-1,2,4-oxadiazole compounds (10a-j) and evaluated for their anticancer activities against a panel of four human cancer cell lines including PC3 & DU-145 (prostate cancer), A549 (lung cancer) and MCF-7 (breast c...

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Main Authors: Rambabu Vasamsetti, Naresh Babu Gatchakayala, Nekuri Bujjibabu, Vudi Sanjeeva Kumar, Tirri Veera Venkata Satyanarayana, Gundu Pavani, Ravi Kumar Kapavarapu, Bandaru Madhav
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Results in Chemistry
Subjects:
Crizotinib
Pyridine
Proxazole
1,2,4-oxadiazole and anticancer activity
Online Access:http://www.sciencedirect.com/science/article/pii/S2211715625002000
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