Differential roles of NaV1.2 and NaV1.6 in neocortical pyramidal cell excitability

Differential roles of NaV1.2 and NaV1.6 in neocortical pyramidal cell excitability

Mature neocortical pyramidal cells functionally express two sodium channel (NaV) isoforms: NaV1.2 and NaV1.6. These isoforms are differentially localized to pyramidal cell compartments, and as such are thought to contribute to different aspects of neuronal excitability. But determining their precise...

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Bibliographic Details
Main Authors: Joshua D Garcia, Chenyu Wang, Ryan PD Alexander, Emmie Banks, Timothy Fenton, Jean-Marc DeKeyser, Tatiana V Abramova, Alfred L George Jr, Roy Ben-Shalom, David H Hackos, Kevin J Bender
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-07-01
Series:eLife
Subjects:
sodium channel
epilepsy
dendrite
pyramidal cell
action potential
Online Access:https://elifesciences.org/articles/105696
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https://elifesciences.org/articles/105696

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