Generation of a new Paneth cell–specific Cre-recombinase transgenic mouse line

Generation of a new Paneth cell–specific Cre-recombinase transgenic mouse line

Paneth cells are located in the crypts of Lieberkühn in mammalian small intestines and are producing antimicrobial peptides to keep the microbiome under control. The genetic manipulation of Paneth cells and their tracking and depletion depend on a solid Paneth cell–specific Cre-transgenic line. Here...

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Bibliographic Details
Main Authors: Natalia Garcia-Gonzalez, Charlotte Wallaeys, Wendy Toussaint, Tino Hochepied, Sylviane Dewaele, Somara De Beul, Robin Van Loke, Jolien Vandewalle, Steven Timmermans, Claude Libert
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
Paneth cells
Defa24iCre
defensins
Cre-recombinase transgenic mouse model
Cre/loxP
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1576995/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1576995/full

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