Down regulation of estrogen receptors (ER; ER) and atypical chemokine receptors (ACKR 2; ACKR3; ACKR4) to increase 17β-estradiol (E2) levels in MCF-7 in-vitro study

Down regulation of estrogen receptors (ER; ER) and atypical chemokine receptors (ACKR 2; ACKR3; ACKR4) to increase 17β-estradiol (E2) levels in MCF-7 in-vitro study

Background: Oestrogen plays a vital role in breast development and is strongly related to breast cancer. This research article delves into this paradox. Inflammation is a cancer hallmark that involve chemokine that attract inflammatory immune cells and promote breast cancer spread. E2 as a potentia...

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Bibliographic Details
Main Author: Shruti Talashi
Format: Article
Language:English
Published: Tehran University of Medical Sciences 2024-10-01
Series:Basic & Clinical Cancer Research
Subjects:
E2 – 17b-estradiol; ACKRs – atypical chemokine receptors; ERa - estrogen receptor alpha; ERb - estrogen receptor beta; RT-qPCR – real-time quantitative polymerase chain reaction.
Online Access:https://bccr.tums.ac.ir/index.php/bccrj/article/view/534
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https://bccr.tums.ac.ir/index.php/bccrj/article/view/534

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