CLK2 Condensates Reorganize Nuclear Speckles and Induce Intron Retention

CLK2 Condensates Reorganize Nuclear Speckles and Induce Intron Retention

Abstract Intron retention (IR) constitutes a less explored form of alternative splicing, wherein introns are retained within mature mRNA transcripts. This investigation demonstrates that the cell division cycle (CDC)‐like kinase 2 (CLK2) undergoes liquid–liquid phase separation (LLPS) within nuclear...

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Bibliographic Details
Main Authors: Bing Wang, Jing Li, Yanyang Song, Xuhui Qin, Xia Lu, Wei Huang, Chentai Peng, Jinxia Wei, Donghui Huang, Wei Wang
Format: Article
Language:English
Published: Wiley 2024-10-01
Series:Advanced Science
Subjects:
CLK2
condensates
heat shock
intron retention
nuclear speckles
Online Access:https://doi.org/10.1002/advs.202309588
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