Effects of nanocurcumin supplementation on metabolic syndrome: A systematic review and meta-analysis of randomized controlled trials
Background: Metabolic syndrome (MetS) encompasses metabolic risk factors like elevated blood glucose, abnormal lipid levels, and hypertension. Nanocurcumin, a nanoscale formulation of curcumin, may offer therapeutic benefits for MetS management. This systematic review and meta-analysis evaluates the...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-03-01
|
| Series: | Pharmacological Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1043661825000660 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832557562760790016 |
|---|---|
| author | Gofarana Wilar Cecep Suhandi Kohji Fukunaga Masanori Shigeno Ichiro Kawahata Rizky Abdulah Takuya Sasaki |
| author_facet | Gofarana Wilar Cecep Suhandi Kohji Fukunaga Masanori Shigeno Ichiro Kawahata Rizky Abdulah Takuya Sasaki |
| author_sort | Gofarana Wilar |
| collection | DOAJ |
| description | Background: Metabolic syndrome (MetS) encompasses metabolic risk factors like elevated blood glucose, abnormal lipid levels, and hypertension. Nanocurcumin, a nanoscale formulation of curcumin, may offer therapeutic benefits for MetS management. This systematic review and meta-analysis evaluates the impact of nanocurcumin supplementation on key MetS parameters. Methods: A systematic literature search identified 20 randomized controlled trials (RCTs) with 1394 participants. Data were pooled using a random-effects model, and standardized mean differences (SMDs) were calculated for key outcomes. Results: Nanocurcumin supplementation significantly improved waist circumference (WC) (standardized mean difference (SMD): −0.30 cm), fasting blood sugar (FBS) (SMD: −0.34 mg/dL), HbA1c (SMD: −0.33 %), and quantitative insulin sensitivity check index (QUICKI) score (SMD: 0.73). Lipid profile parameters, including total cholesterol (SMD: −0.18 mg/dL), LDL-C (SMD: −0.16 mg/dL), and HDL-C (SMD: 0.32 mg/dL), also reduced significantly. Improvement in diastolic blood pressure (DBP) (SMD: −0.32 mmHg), total antioxidant capacity (TAC) (SMD: 0.44 mmol/L), malondialdehyde (MDA) (SMD: −0.37 mmol/L), tumor necrosis factor-α (TNF-α) (SMD: −2.30 ng/L), interleukin-6 (IL-6) (SMD: −1.07 ng/L), and high-sensitivity C-reactive protein (hs-CRP) (SMD: −0.34 mg/L) were observed. Conclusion: Nanocurcumin supplementation significantly improves multiple MetS-related parameters, including anthropometric measures, glycemic control, lipid profile, blood pressure, oxidative stress markers, and inflammatory biomarkers. These findings highlight nanocurcumin's potential as an effective adjunctive therapy for managing MetS. However, the variability in study participant ages, treatment durations, and sample sizes suggests the need for further well-designed RCTs to establish optimal usage guidelines. |
| format | Article |
| id | doaj-art-0bc762098f9f477e8d7cec7565f8d6cc |
| institution | Kabale University |
| issn | 1096-1186 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pharmacological Research |
| spelling | doaj-art-0bc762098f9f477e8d7cec7565f8d6cc2025-02-03T04:16:29ZengElsevierPharmacological Research1096-11862025-03-01213107641Effects of nanocurcumin supplementation on metabolic syndrome: A systematic review and meta-analysis of randomized controlled trialsGofarana Wilar0Cecep Suhandi1Kohji Fukunaga2Masanori Shigeno3Ichiro Kawahata4Rizky Abdulah5Takuya Sasaki6Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang 45363, Indonesia; Corresponding author.Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang 45363, Indonesia; Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang 45363, IndonesiaDepartment of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan; Department of CNS Drug Innovation, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, JapanDepartment of Biophysical Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, JapanDepartment of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, JapanDepartment of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang 45363, IndonesiaDepartment of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, JapanBackground: Metabolic syndrome (MetS) encompasses metabolic risk factors like elevated blood glucose, abnormal lipid levels, and hypertension. Nanocurcumin, a nanoscale formulation of curcumin, may offer therapeutic benefits for MetS management. This systematic review and meta-analysis evaluates the impact of nanocurcumin supplementation on key MetS parameters. Methods: A systematic literature search identified 20 randomized controlled trials (RCTs) with 1394 participants. Data were pooled using a random-effects model, and standardized mean differences (SMDs) were calculated for key outcomes. Results: Nanocurcumin supplementation significantly improved waist circumference (WC) (standardized mean difference (SMD): −0.30 cm), fasting blood sugar (FBS) (SMD: −0.34 mg/dL), HbA1c (SMD: −0.33 %), and quantitative insulin sensitivity check index (QUICKI) score (SMD: 0.73). Lipid profile parameters, including total cholesterol (SMD: −0.18 mg/dL), LDL-C (SMD: −0.16 mg/dL), and HDL-C (SMD: 0.32 mg/dL), also reduced significantly. Improvement in diastolic blood pressure (DBP) (SMD: −0.32 mmHg), total antioxidant capacity (TAC) (SMD: 0.44 mmol/L), malondialdehyde (MDA) (SMD: −0.37 mmol/L), tumor necrosis factor-α (TNF-α) (SMD: −2.30 ng/L), interleukin-6 (IL-6) (SMD: −1.07 ng/L), and high-sensitivity C-reactive protein (hs-CRP) (SMD: −0.34 mg/L) were observed. Conclusion: Nanocurcumin supplementation significantly improves multiple MetS-related parameters, including anthropometric measures, glycemic control, lipid profile, blood pressure, oxidative stress markers, and inflammatory biomarkers. These findings highlight nanocurcumin's potential as an effective adjunctive therapy for managing MetS. However, the variability in study participant ages, treatment durations, and sample sizes suggests the need for further well-designed RCTs to establish optimal usage guidelines.http://www.sciencedirect.com/science/article/pii/S1043661825000660NanocurcuminMetabolic syndromeInflammatory markersOxidative stressMeta-analysis |
| spellingShingle | Gofarana Wilar Cecep Suhandi Kohji Fukunaga Masanori Shigeno Ichiro Kawahata Rizky Abdulah Takuya Sasaki Effects of nanocurcumin supplementation on metabolic syndrome: A systematic review and meta-analysis of randomized controlled trials Pharmacological Research Nanocurcumin Metabolic syndrome Inflammatory markers Oxidative stress Meta-analysis |
| title | Effects of nanocurcumin supplementation on metabolic syndrome: A systematic review and meta-analysis of randomized controlled trials |
| title_full | Effects of nanocurcumin supplementation on metabolic syndrome: A systematic review and meta-analysis of randomized controlled trials |
| title_fullStr | Effects of nanocurcumin supplementation on metabolic syndrome: A systematic review and meta-analysis of randomized controlled trials |
| title_full_unstemmed | Effects of nanocurcumin supplementation on metabolic syndrome: A systematic review and meta-analysis of randomized controlled trials |
| title_short | Effects of nanocurcumin supplementation on metabolic syndrome: A systematic review and meta-analysis of randomized controlled trials |
| title_sort | effects of nanocurcumin supplementation on metabolic syndrome a systematic review and meta analysis of randomized controlled trials |
| topic | Nanocurcumin Metabolic syndrome Inflammatory markers Oxidative stress Meta-analysis |
| url | http://www.sciencedirect.com/science/article/pii/S1043661825000660 |
| work_keys_str_mv | AT gofaranawilar effectsofnanocurcuminsupplementationonmetabolicsyndromeasystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT cecepsuhandi effectsofnanocurcuminsupplementationonmetabolicsyndromeasystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT kohjifukunaga effectsofnanocurcuminsupplementationonmetabolicsyndromeasystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT masanorishigeno effectsofnanocurcuminsupplementationonmetabolicsyndromeasystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT ichirokawahata effectsofnanocurcuminsupplementationonmetabolicsyndromeasystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT rizkyabdulah effectsofnanocurcuminsupplementationonmetabolicsyndromeasystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT takuyasasaki effectsofnanocurcuminsupplementationonmetabolicsyndromeasystematicreviewandmetaanalysisofrandomizedcontrolledtrials |