<i>In Vitro</i> and <i>In Vivo</i> Evaluation of the Antischistosomal Activity of Polygodial and 9-Deoxymuzigadial Isolated from <i>Drimys brasiliensis</i> Branches

<i>In Vitro</i> and <i>In Vivo</i> Evaluation of the Antischistosomal Activity of Polygodial and 9-Deoxymuzigadial Isolated from <i>Drimys brasiliensis</i> Branches

In the present study, the hexane extract from branches of <i>Drimys brasiliensis</i> (Winteraceae) displayed potent activity against <i>Schistosoma mansoni</i> parasites (100% mortality of the worms at 200 μg/mL). Bioactivity-guided fractionation afforded, in addition to the...

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Bibliographic Details
Main Authors: Eric Umehara, Rayssa A. Cajas, Gabriel B. Conceição, Guilherme M. Antar, Adriano D. Andricopulo, Josué de Moraes, João Henrique G. Lago
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Molecules
Subjects:
antischistosomal activity
polygodial
9-deoxymuzigadial
<i>Drimys brasiliensis</i>
schistosomiasis
Online Access:https://www.mdpi.com/1420-3049/30/2/267
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