Cell Mechanisms of Post-Mortem Excitability of Skeletal Muscle
<b>Background/Objectives:</b> The excitability of skeletal muscle is a less-known post-mortem supravital phenomenon in human bodies, and it can be used to estimate the post-mortem interval. We conducted a field study in the Netherlands to investigate the applicability of muscle excitabil...
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MDPI AG
2025-01-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/13/1/221 |
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| author | H. Stigter T. Krap W. L. J. M. Duijst |
| author_facet | H. Stigter T. Krap W. L. J. M. Duijst |
| author_sort | H. Stigter |
| collection | DOAJ |
| description | <b>Background/Objectives:</b> The excitability of skeletal muscle is a less-known post-mortem supravital phenomenon in human bodies, and it can be used to estimate the post-mortem interval. We conducted a field study in the Netherlands to investigate the applicability of muscle excitability (SMR) by mechanical stimulation for estimating the post-mortem interval in daily forensic practice. Knowledge concerning the post-mortem cell mechanisms accounting for the post-mortem excitability of skeletal muscle is lacking. Cell mechanisms are the specific intracellular and biochemical processes responsible for post-mortem muscle excitability. <b>Methods:</b> We have studied the theoretical backgrounds of the cell mechanisms that might be responsible for post-mortem muscle excitability, by performing literature research via the databank PubMed. <b>Results:</b> Based on the current available literature, in our opinion the intracellular changes in muscle cells that are responsible for SMR resemble the intracellular processes responsible for muscle fatigue due to energy exhaustion in the living. <b>Conclusions:</b> We hypothesize two pathways, depending on the level of energy in the muscle cell, that could be responsible for post-mortem muscle excitability by mechanical stimulation. |
| format | Article |
| id | doaj-art-0bb0c62625b84cda976e268b33b2e514 |
| institution | Kabale University |
| issn | 2227-9059 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
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| series | Biomedicines |
| spelling | doaj-art-0bb0c62625b84cda976e268b33b2e5142025-01-24T13:24:27ZengMDPI AGBiomedicines2227-90592025-01-0113122110.3390/biomedicines13010221Cell Mechanisms of Post-Mortem Excitability of Skeletal MuscleH. Stigter0T. Krap1W. L. J. M. Duijst2Faculty of Law and Criminology, Maastricht University, Minderbroedersberg 4–6, 6211 LK Maastricht, The NetherlandsFaculty of Law and Criminology, Maastricht University, Minderbroedersberg 4–6, 6211 LK Maastricht, The NetherlandsFaculty of Law and Criminology, Maastricht University, Minderbroedersberg 4–6, 6211 LK Maastricht, The Netherlands<b>Background/Objectives:</b> The excitability of skeletal muscle is a less-known post-mortem supravital phenomenon in human bodies, and it can be used to estimate the post-mortem interval. We conducted a field study in the Netherlands to investigate the applicability of muscle excitability (SMR) by mechanical stimulation for estimating the post-mortem interval in daily forensic practice. Knowledge concerning the post-mortem cell mechanisms accounting for the post-mortem excitability of skeletal muscle is lacking. Cell mechanisms are the specific intracellular and biochemical processes responsible for post-mortem muscle excitability. <b>Methods:</b> We have studied the theoretical backgrounds of the cell mechanisms that might be responsible for post-mortem muscle excitability, by performing literature research via the databank PubMed. <b>Results:</b> Based on the current available literature, in our opinion the intracellular changes in muscle cells that are responsible for SMR resemble the intracellular processes responsible for muscle fatigue due to energy exhaustion in the living. <b>Conclusions:</b> We hypothesize two pathways, depending on the level of energy in the muscle cell, that could be responsible for post-mortem muscle excitability by mechanical stimulation.https://www.mdpi.com/2227-9059/13/1/221cell mechanismspost-mortemexcitabilityskeletalmuscle |
| spellingShingle | H. Stigter T. Krap W. L. J. M. Duijst Cell Mechanisms of Post-Mortem Excitability of Skeletal Muscle Biomedicines cell mechanisms post-mortem excitability skeletal muscle |
| title | Cell Mechanisms of Post-Mortem Excitability of Skeletal Muscle |
| title_full | Cell Mechanisms of Post-Mortem Excitability of Skeletal Muscle |
| title_fullStr | Cell Mechanisms of Post-Mortem Excitability of Skeletal Muscle |
| title_full_unstemmed | Cell Mechanisms of Post-Mortem Excitability of Skeletal Muscle |
| title_short | Cell Mechanisms of Post-Mortem Excitability of Skeletal Muscle |
| title_sort | cell mechanisms of post mortem excitability of skeletal muscle |
| topic | cell mechanisms post-mortem excitability skeletal muscle |
| url | https://www.mdpi.com/2227-9059/13/1/221 |
| work_keys_str_mv | AT hstigter cellmechanismsofpostmortemexcitabilityofskeletalmuscle AT tkrap cellmechanismsofpostmortemexcitabilityofskeletalmuscle AT wljmduijst cellmechanismsofpostmortemexcitabilityofskeletalmuscle |