A variant of the autophagic receptor NDP52 counteracts phospho-TAU accumulation and emerges as a protective factor for Alzheimer’s disease

A variant of the autophagic receptor NDP52 counteracts phospho-TAU accumulation and emerges as a protective factor for Alzheimer’s disease

Abstract Selective elimination of early pathological TAU species may be a promising therapeutic strategy to reduce the accumulation of TAU, which contributes to neurodegeneration and is a hallmark of Alzheimer’s disease (AD). Pathological hyper-phosphorylated TAU can be degraded through selective au...

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Main Authors: Anna Mattioni, Claudia Carsetti, Krenare Bruqi, Valerio Caputo, Valentina Cianfanelli, Maria Giulia Bacalini, Mariella Casa, Carlo Gabelli, Emiliano Giardina, Gianluca Cestra, Flavie Strappazzon
Format: Article
Language:English
Published: Nature Publishing Group 2025-04-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07611-2
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https://doi.org/10.1038/s41419-025-07611-2

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