Evaluation of Innate Immune System, Body Habitus, and Sex on the Pharmacokinetics and Pharmacodynamics of Anetumab Ravtansine in Patients With Cancer

Evaluation of Innate Immune System, Body Habitus, and Sex on the Pharmacokinetics and Pharmacodynamics of Anetumab Ravtansine in Patients With Cancer

ABSTRACT Anetumab ravtansine, like other ADC drugs, has high inter‐patient variability in its pharmacokinetic (PK) and pharmacodynamic (PD) outcomes, which raises concerns about whether current dosing regimens are optimal for patients. The objective of this study was to evaluate covariates, especial...

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Bibliographic Details
Main Authors: Li Chen, Andrew T. Lucas, Aaron S. Mansfield, Stephanie Lheureux, Claire O'Connor, Beth A. Zamboni, Kashish Patel, Tawnya McKee, Jeffrey Moscow, William C. Zamboni
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:Clinical and Translational Science
Subjects:
anetumab ravtansine
antibody‐drug conjugate
body habitus
innate immune system
pharmacodynamics
pharmacokinetics
Online Access:https://doi.org/10.1111/cts.70178
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https://doi.org/10.1111/cts.70178

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