Ventricular-arterial coupling: changes with ageing and implications across cardiovascular conditions
Purpose Ventricular-arterial coupling (VAC) is a crucial concept in cardiovascular physiology, representing the dynamic interaction between the left ventricle and the arterial system. This comprehensive literature review explores the changes in VAC with ageing and various cardiovascular diseases (CV...
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| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Blood Pressure |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/08037051.2025.2457698 |
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| author | Mateusz Gaczoł Marek Rajzer Wiktoria Wojciechowska |
| author_facet | Mateusz Gaczoł Marek Rajzer Wiktoria Wojciechowska |
| author_sort | Mateusz Gaczoł |
| collection | DOAJ |
| description | Purpose Ventricular-arterial coupling (VAC) is a crucial concept in cardiovascular physiology, representing the dynamic interaction between the left ventricle and the arterial system. This comprehensive literature review explores the changes in VAC with ageing and various cardiovascular diseases (CVDs).Materials and methods This literature review covers studies on changes in VAC with age and common CVDs, such as arterial hypertension, atrial fibrillation (AF) and heart failure with preserved and reduced ejection fraction and aortic stenosis (AS). The review discusses traditional measures of VAC, including arterial elastance (Ea) and ventricular elastance (Ees), as well as emerging parameters, such as global longitudinal strain (GLS) and pulse wave velocity (PWV). The review introduces the PWV/GLS ratio as a novel method for assessing VAC.Results With ageing, both Ea and Ees increase, while the Ea/Ees ratio remains relatively stable, reflecting balanced arterial and ventricular adaptations. Novel measures, such as PWV/GLS ratio, show greater impairment in older adults and provide a comprehensive evaluation of VAC.Conclusions Ageing disrupts VAC through arterial stiffening and reduced heart function, often exacerbated by CVDs. Novel metrics like PWV/GLS may improve VAC assessment, helping clinicians manage age-related cardiovascular issues by identifying risks earlier and guiding treatment to support efficient heart–artery interaction. |
| format | Article |
| id | doaj-art-0b7438d571b74903af7ccf93c3a1a9c0 |
| institution | Kabale University |
| issn | 0803-7051 1651-1999 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Blood Pressure |
| spelling | doaj-art-0b7438d571b74903af7ccf93c3a1a9c02025-02-05T14:23:48ZengTaylor & Francis GroupBlood Pressure0803-70511651-19992025-12-0134110.1080/08037051.2025.2457698Ventricular-arterial coupling: changes with ageing and implications across cardiovascular conditionsMateusz Gaczoł0Marek Rajzer1Wiktoria Wojciechowska21st Department of Cardiology, Interventional Electrocardiology and Arterial Hypertension, Jagiellonian University Medical College, Kraków, Poland1st Department of Cardiology, Interventional Electrocardiology and Arterial Hypertension, Jagiellonian University Medical College, Kraków, Poland1st Department of Cardiology, Interventional Electrocardiology and Arterial Hypertension, Jagiellonian University Medical College, Kraków, PolandPurpose Ventricular-arterial coupling (VAC) is a crucial concept in cardiovascular physiology, representing the dynamic interaction between the left ventricle and the arterial system. This comprehensive literature review explores the changes in VAC with ageing and various cardiovascular diseases (CVDs).Materials and methods This literature review covers studies on changes in VAC with age and common CVDs, such as arterial hypertension, atrial fibrillation (AF) and heart failure with preserved and reduced ejection fraction and aortic stenosis (AS). The review discusses traditional measures of VAC, including arterial elastance (Ea) and ventricular elastance (Ees), as well as emerging parameters, such as global longitudinal strain (GLS) and pulse wave velocity (PWV). The review introduces the PWV/GLS ratio as a novel method for assessing VAC.Results With ageing, both Ea and Ees increase, while the Ea/Ees ratio remains relatively stable, reflecting balanced arterial and ventricular adaptations. Novel measures, such as PWV/GLS ratio, show greater impairment in older adults and provide a comprehensive evaluation of VAC.Conclusions Ageing disrupts VAC through arterial stiffening and reduced heart function, often exacerbated by CVDs. Novel metrics like PWV/GLS may improve VAC assessment, helping clinicians manage age-related cardiovascular issues by identifying risks earlier and guiding treatment to support efficient heart–artery interaction.https://www.tandfonline.com/doi/10.1080/08037051.2025.2457698Ventricular-arterial couplingEa/EesPWV/GLSageingelderly |
| spellingShingle | Mateusz Gaczoł Marek Rajzer Wiktoria Wojciechowska Ventricular-arterial coupling: changes with ageing and implications across cardiovascular conditions Blood Pressure Ventricular-arterial coupling Ea/Ees PWV/GLS ageing elderly |
| title | Ventricular-arterial coupling: changes with ageing and implications across cardiovascular conditions |
| title_full | Ventricular-arterial coupling: changes with ageing and implications across cardiovascular conditions |
| title_fullStr | Ventricular-arterial coupling: changes with ageing and implications across cardiovascular conditions |
| title_full_unstemmed | Ventricular-arterial coupling: changes with ageing and implications across cardiovascular conditions |
| title_short | Ventricular-arterial coupling: changes with ageing and implications across cardiovascular conditions |
| title_sort | ventricular arterial coupling changes with ageing and implications across cardiovascular conditions |
| topic | Ventricular-arterial coupling Ea/Ees PWV/GLS ageing elderly |
| url | https://www.tandfonline.com/doi/10.1080/08037051.2025.2457698 |
| work_keys_str_mv | AT mateuszgaczoł ventriculararterialcouplingchangeswithageingandimplicationsacrosscardiovascularconditions AT marekrajzer ventriculararterialcouplingchangeswithageingandimplicationsacrosscardiovascularconditions AT wiktoriawojciechowska ventriculararterialcouplingchangeswithageingandimplicationsacrosscardiovascularconditions |