Leucine-rich alpha-2-glycoprotein 1 deficiency suppresses ischemia–reperfusion injury-induced renal fibrosis

Leucine-rich alpha-2-glycoprotein 1 deficiency suppresses ischemia–reperfusion injury-induced renal fibrosis

Abstract Ischemia reperfusion injury (IRI) is a major cause of acute kidney injury (AKI) and ultimately leads to renal fibrosis, primarily via the transforming growth factor-β (TGF-β) pathway. Leucine-rich alpha-2-glycoprotein 1 (LRG1), a novel modulator of the TGF-β pathway, has been implicated in...

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Main Authors: Naohito Okami, Hiromichi Wakui, Kengo Azushima, Tomohito Miyazawa, Eisuke Kubo, Shunichiro Tsukamoto, Mari Sotozawa, Shinya Taguchi, Shingo Urate, Kohei Ishiga, Sho Kinguchi, Tomohiko Kanaoka, Kouichi Tamura
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Ischemia–reperfusion injury
Acute kidney disease
Fibrosis
Leucine-rich alpha-2-glycoprotein 1
Transforming growth factor β
Online Access:https://doi.org/10.1038/s41598-024-84798-y
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https://doi.org/10.1038/s41598-024-84798-y

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